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Therefore, the purpose of this study was to measure baseline plasma VEGF and changes in VEGF over the course of fractionated radiation therapy in dogs with spontaneous tumors. Dogs with tumors had a significantly higher pretreatment plasma VEGF than did dogs without tumors. Immediately after irradiation no increased plasma VEGF was observed. Over the course of radiation therapy there was an increased plasma VEGF in dogs treated with low doses per fraction\/high total dose, whereas plasma VEGF remained stable in dogs irradiated with high doses per fraction\/low total dose. The regulatory mechanisms are very complex, and therefore the value of plasma VEGF measurements as an indirect marker of angiogenesis induced by radiotherapy is limited.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2004.04045.x","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T18:24:42Z","timestamp":1085509482000},"page":"247-254","source":"Crossref","is-referenced-by-count":23,"title":["Preliminary study of plasma vascular endothelial growth factor (VEGF) during low\u2010 and high\u2010dose radiation therapy of dogs with spontaneous tumors"],"prefix":"10.1111","volume":"45","author":[{"given":"Melanie C.","family":"Wergin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Ballmer\u2010Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.","family":"Achermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Inteeworn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete K.","family":"Akens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Blattmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kaser\u2010Hotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.1.0287"},{"key":"e_1_2_6_3_2","first-page":"1806","article-title":"The vascular growth factor family","volume":"5","author":"Houck KA","year":"1991","journal-title":"idenepsication of a fourth molecular species and characterization of alternative splicing of RNA"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/roi.2970020604"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.64.453"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.187"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.603"},{"key":"e_1_2_6_8_2","first-page":"419","article-title":"The vesiculo\u2010vacuolare organelle (VVO)","volume":"49","author":"Dvorak AM","year":"2001","journal-title":"a new endothelial cell permeability organelle"},{"key":"e_1_2_6_9_2","first-page":"765","article-title":"Neovasculature induced by vascular endothelial growth factor is fenestrated","volume":"57","author":"Roberts WG","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-suppl_1-3"},{"key":"e_1_2_6_11_2","first-page":"203","article-title":"Regulation of angiogenesis via vascular endothelial growth factor receptors","volume":"60","author":"Veikkola T","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_2","first-page":"3374","article-title":"Blockade of the vascular endothelial growth factor stress response increases the antitumor effect of ionizing radiation","volume":"59","author":"Gorski DH","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00017"},{"key":"e_1_2_6_14_2","first-page":"119","article-title":"Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma","volume":"54","author":"Sheng H","year":"2000","journal-title":"Acta Med Okayama"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960301)77:5<858::AID-CNCR8>3.0.CO;2-A"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","unstructured":"LoncasterJA CopperRA LogueJP DavidsonSE HunterRD WestCM. 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