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No difference was observed for acute or late radiation effects. Cisplatin was administered at a dosage of 7.5\u2003mg\/m<jats:sup>2<\/jats:sup>20\u2003min prior to every other radiation treatment. An initial dose of 10\u2003mg\/m<jats:sup>2<\/jats:sup>was intended but toxicity (primarily azotemia) was unacceptable. Cisplatin was administered as prescribed in 12 of 18 dogs. Cisplatin was discontinued in 2 dogs because of azotemia. In the other 4 dogs cisplatin was not administered as prescribed because the dogs were withdrawn from treatment due to disease progression or radiation effects. There was no long\u2010term renal disease in patients who developed azotemia. The overall median survival was 433 days with 4 (12.9%) dogs still alive at the completion of the study.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2004.04068.x","type":"journal-article","created":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T09:34:01Z","timestamp":1091612041000},"page":"362-367","source":"Crossref","is-referenced-by-count":26,"title":["Cobalt Radiation with or without Low\u2010Dose Cisplatin for Treatment of Canine Naso\u2010Sinus Carcinomas"],"prefix":"10.1111","volume":"45","author":[{"given":"Marie\u2010Eve","family":"Nadeau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.","family":"Kitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Rooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan 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