{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:32:09Z","timestamp":1770215529079,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>The objective of this study was to document changes in echocardiographic variables of left ventricular size and function noninvasively during acute normovolemic anemia. This model was developed as a pilot study with the purpose of providing baseline information to investigate the pathophysiology, and more specifically the effect on the heart, of canine babesiosis\u2010induced anemia. The study group comprised of 11 mature healthy Beagle dogs that weighed between 9 and 15\u2003kg. Severe normovolemic anemia was induced over a 3\u20134\u2010day period by serial bleeding while maintaining normovolemia by autotransfusing plasma and infusing crystalloids. The dogs were then allowed to recover. Preanemic (mean Hct 46.7%, standard deviation [SD] 2.4%) echocardiographic variables of left ventricular performance (Fractional shortening, ejection fraction, end\u2010systolic and end\u2010diastolic ventricular volumes, cardiac index, and heart rate) were compared with those in the severely (mean Hct 15.3%, SD 1.1%), moderately (Hct mean 24.7%, SD 1.5%), and mildly (mean Hct 33.5%, SD 2.5%) anemic states, and between the anemic states. With the exception of end diastolic volume, there was a statistically significant (<jats:italic>P<\/jats:italic>&lt;0.05) increase in all variables in the severely anemic state vs. the preanemic and the mild and moderate anemic states. In concordance with previous invasive models, a hyperdynamic state of the left ventricle develops in response to experimentally induced acute canine normovolemic anemia in the conscious dog. Echocardiography has promise as a noninvasive technique of evaluating the cardiac changes in dogs having canine babesiosis.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2006.00154.x","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T10:02:42Z","timestamp":1150970562000},"page":"358-365","source":"Crossref","is-referenced-by-count":16,"title":["CHANGES IN ECHOCARDIOGRAPHIC VARIABLES OF LEFT VENTRICULAR SIZE AND FUNCTION IN A MODEL OF CANINE NORMOVOLEMIC ANEMIA"],"prefix":"10.1111","volume":"47","author":[{"given":"TIM C.","family":"SPOTSWOOD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT M.","family":"KIRBERGER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEE M.P.K.","family":"KOMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER 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