{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:44:50Z","timestamp":1763747090602,"version":"3.40.2"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Spondylosis deformans and diffuse idiopathic skeletal hyperostosis (<jats:styled-content style=\"fixed-case\">DISH<\/jats:styled-content>) are usually incidental findings and in most dogs are either asymptomatic or associated with mild clinical signs. Severe spondylosis deformans and<jats:styled-content style=\"fixed-case\">DISH<\/jats:styled-content>can result in complete bony fusion of consecutive vertebral segments. One of the recognised complications following vertebral fusion in human patients is the development of adjacent segment disease, which is defined as degenerative changes, most commonly degenerative intervertebral disc disease, in the mobile vertebral segment neighboring a region of complete vertebral fusion. A similar syndrome following cervical fusion in dogs has been termed the domino effect. The purpose of this retrospective study was to investigate the hypothesis that vertebral fusion occurring secondary to spondylosis deformans or<jats:styled-content style=\"fixed-case\">DISH<\/jats:styled-content>in dogs would protect fused intervertebral disc spaces from undergoing degeneration, but result in adjacent segment disease at neighbouring unfused intervertebral disc spaces. Eight dogs with clinical signs of thoracolumbar myelopathy, magnetic resonance imaging of the thoracolumbar vertebral column, and spondylosis deformans or<jats:styled-content style=\"fixed-case\">DISH<\/jats:styled-content>producing fusion of \u22652 consecutive intervertebral disc spaces were evaluated. Vertebral fusion of \u22652 consecutive intervertebral disc spaces was correlated (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>= 0.0017) with adjacent segment disease at the neighbouring unfused intervertebral disc space. Vertebral fusion appeared to protect fused intervertebral disc spaces from undergoing degeneration (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>&lt; 0.0001). Adjacent segment disease should be considered in dogs with severe spondylosis deformans or<jats:styled-content style=\"fixed-case\">DISH<\/jats:styled-content>occurring in conjunction with a thoracolumbar myelopathy.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2011.01891.x","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T12:39:17Z","timestamp":1332592757000},"page":"128-134","source":"Crossref","is-referenced-by-count":25,"title":["SPONDYLOSIS DEFORMANS AND DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (<scp>DISH<\/scp>) RESULTING IN ADJACENT SEGMENT DISEASE"],"prefix":"10.1111","volume":"53","author":[{"given":"Maria","family":"Ortega","sequence":"first","affiliation":[{"name":"From the School of Veterinary Medicine College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G61 1QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science Small Animal Teaching Hospital University of Liverpool Leahurst Neston CH64 7TE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Haley","sequence":"additional","affiliation":[{"name":"From the School of Veterinary Medicine College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G61 1QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Wessmann","sequence":"additional","affiliation":[{"name":"From the School of Veterinary Medicine College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G61 1QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Penderis","sequence":"additional","affiliation":[{"name":"From the School of Veterinary Medicine College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G61 1QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199503150-00018"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200007150-00016"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-200104000-00001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2460\/javma.1994.205.09.1297","article-title":"Observation of a secondary compressive lesion after treatment of caudal cervical spondylomyelopathy in a dog","volume":"205","author":"Wilson ER","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000137069.88904.03"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199603010-00004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200111150-00024"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1967.tb04526.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02872.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2527\/2004.82185x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.04.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1968.tb04605.x"},{"key":"e_1_2_5_14_1","first-page":"7","article-title":"Spondylosis derformans in the dog. 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