{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:32:27Z","timestamp":1791304347363,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>The purpose of this retrospective study was to determine if 4<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y fractions over 5 consecutive days is an effective and safe palliative radiation protocol for dogs and cats. Eighty patients (22 cats, 58 dogs) with complete follow\u2010up information were evaluated. Overall response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) for all patients was 67%. Median progression free survival (<jats:styled-content style=\"fixed-case\">MPFS<\/jats:styled-content>) was 3.3 months and median survival (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>) was 4.2 months. Primary bone tumors were the most common tumors treated. The<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>for primary bone tumors was 66.6%, the<jats:styled-content style=\"fixed-case\">MPFS<\/jats:styled-content>was 3.5 months, and<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>was 3 months. The most common tumor treated in cats was oral squamous cell carcinoma and<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>was 54.5 %, the<jats:styled-content style=\"fixed-case\">MPFS<\/jats:styled-content>was 1.8 months, and<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>was 3 months. Soft tissue sarcomas were the second most common tumor treated in dogs (10).<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>was 80% and the two other patients had stable disease.<jats:styled-content style=\"fixed-case\">MPFS<\/jats:styled-content>was 5.7 months and<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>was 7.9 months. Overall rate of toxicity was 18.4% in 65 sites that were evaluated for toxicity. Acute toxicities were all grade I or II and occurred in 16.9 % of patients evaluated. All late toxicity was grade I alopecia and leukotrichia. There appears to be a comparable response rate for this palliative protocol as compared to others historically. This response was seen over a wide range of tumors. We also documented a low toxicity profile in a shorter overall treatment time, making this protocol more attractive for some clients.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2011.01907.x","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T04:17:39Z","timestamp":1324354659000},"page":"358-364","source":"Crossref","is-referenced-by-count":42,"title":["RESPONSE RATE AND DURATION ASSOCIATED WITH A 4<scp>G<\/scp>Y 5 FRACTION PALLIATIVE RADIATION PROTOCOL"],"prefix":"10.1111","volume":"53","author":[{"given":"Catie","family":"McDonald","sequence":"first","affiliation":[{"name":"Radiation Oncology VCA Aurora Animal Hospital Aurora IL 60506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayme","family":"Looper","sequence":"additional","affiliation":[{"name":"Radiation Oncology VCA Aurora Animal Hospital Aurora IL 60506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna","family":"Greene","sequence":"additional","affiliation":[{"name":"Medical Oncology VCA Aurora Animal Hospital Aurora IL 60506"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00090.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/0430187"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01661.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440100"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.1471"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00097.x"},{"key":"e_1_2_5_8_1","first-page":"415","article-title":"Efficacy of radiation therapy for the treatment of macroscopic canine oral soft tissue sarcoma","volume":"3","author":"Poirier VJ","year":"2006","journal-title":"In Vivo"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03257.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2460\/javma.1996.209.01.98","article-title":"Radiotherapy of oral malignant melanomas in dogs","volume":"1","author":"Blackwood L","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_11_1","first-page":"96","article-title":"Treatment of dogs with oral melanoma by hypofractionated radiation therapy and platinum\u2010based chemotherapy (1987\u20131997)","volume":"1","author":"Freeman KP","year":"2003","journal-title":"J Vet Intern Med Assoc"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00468.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03061.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00907.x"},{"key":"e_1_2_5_15_1","first-page":"309","article-title":"Radiation therapy for tumors of the nasal cavity and paranasal sinuses in dogs","volume":"3","author":"Elliot KM","year":"2009","journal-title":"Can Vet J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440116"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1999.tb00367.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2007.00133.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400131"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01242.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0221.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.5326\/0450024"},{"key":"e_1_2_5_23_1","first-page":"713","article-title":"Palliative radiotherapy with electrons of appendicular osteosarcoma in 54 dogs","volume":"4","author":"Mueller F","year":"2005","journal-title":"In Vivo"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1999.tb00385.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380445"},{"key":"e_1_2_5_26_1","first-page":"391","volume-title":"Radiobiology for the Radiologist","author":"Hall EJ","year":"2006"},{"key":"e_1_2_5_27_1","first-page":"209","article-title":"Normal tissue tolerance and management of radiation injury","volume":"3","author":"Gillette SM","year":"1995","journal-title":"Sem Vet Med Surg"}],"container-title":["Veterinary Radiology &amp; 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