{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:05:21Z","timestamp":1771848321888,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian Animal Cancer Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Squamous cell carcinoma (SCC) is the most common feline oral tumor. Standard radiation protocols have been reported to achieve tumor control durations of 1.5\u20135.5 months (45\u2013165 days). The purpose of this study was to describe the efficacy and toxicity of an accelerated hypofractionated radiation therapy protocol in cats with oral SCC. Twenty\u2010one cats with histologically confirmed oral SCC and T1\u20103N0M0 were treated with 10 once\u2010daily fractions (Monday\u2013Friday) of 4.8 Gy. Seventeen cats had macroscopic disease and four were microscopic after incomplete excision. Acute toxicity consisted of grade 2 mucositis in all cats and this was effectively managed using esophageal or gastric tube feeding, pain medication, and antibiotics. Late toxicity effects for cats with available follow\u2010up data included alopecia (4 cats), leukotricia (6), tongue ulceration (1), and oronasal fistula (1). Response could be assessed in 17 cats (seven complete response and five partial response). Four cats (19%) developed metastatic disease without evidence of local progression. The median progression\u2010free survival (PFS) was 105 days (1 year PFS of 23%), median local progression\u2010free survival (LPFS) was 219 days (1 year LPFS of 41%), and median overall survival (OS) was 174 days (1 year OS of 29%). Only tumor stage was prognostic, with T1 having a median PFS of 590 days. Findings indicated that this accelerated hypofractionated radiation therapy protocol was well tolerated in cats with oral SCC, with manageable adverse events. Tumor response was observed in most cats and long tumor control durations were achieved in some cats.<\/jats:p>","DOI":"10.1111\/j.1740-8261.2012.01970.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T14:26:51Z","timestamp":1444746411000},"page":"81-88","source":"Crossref","is-referenced-by-count":44,"title":["EFFICACY AND TOXICITY OF AN ACCELERATED HYPOFRACTIONATED RADIATION THERAPY PROTOCOL IN CATS WITH ORAL SQUAMOUS CELL CARCINOMA"],"prefix":"10.1111","volume":"54","author":[{"given":"Val\u00e9rie J.","family":"Poirier","sequence":"first","affiliation":[{"name":"Australian Animal Cancer Foundation Brisbane Veterinary Specialist Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kaser\u2010Hotz","sequence":"additional","affiliation":[{"name":"AOI Animal Oncology and Imaging Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Vail","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney C.","family":"Straw","sequence":"additional","affiliation":[{"name":"Australian Animal Cancer Foundation Brisbane Veterinary Specialist Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588902600204"},{"key":"e_1_2_6_3_1","first-page":"305","volume-title":"Small animal clinical oncology","author":"Withrow SJ","year":"2001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-3-209"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1939-1676.2003.tb02478.x","article-title":"Environmental and lifestyle risk factors for oral squamous cell carcinoma in dometic cats","volume":"1","author":"Bertone ER","year":"2003","journal-title":"J Vet Intern Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2460\/javma.1984.184.04.460","article-title":"Mandibular resection for removal of oral tumors in 30 dogs and 6 cats","volume":"184","author":"Bradley RL","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1986.tb00168.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/0420350"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1972.tb06319.x"},{"key":"e_1_2_6_10_1","first-page":"438","article-title":"Oral squamous cell carcinoma in the cat","volume":"29","author":"Reeves NC","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2460\/javma.1992.201.05.777","article-title":"Treatment of mandibular squamous cell carcinoma in cats by use of mandibulectomy and radiotherapy: seven cases (1987\u20131989)","volume":"201","author":"Hutson CA","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_12_1","first-page":"463","article-title":"Gemcitabine as radiosensitizer for nonresectable feline oral squamous cell carcinoma","volume":"39","author":"Jones PD","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00907.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90012-S"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0721.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02914.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006087114421"},{"key":"e_1_2_6_18_1","first-page":"397","volume-title":"Radiobiology for the radiologists","author":"Hall EJ","year":"2000"},{"key":"e_1_2_6_19_1","volume-title":"TNM classification of tumors in domestic animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_6_20_1","first-page":"205","volume-title":"J Natl Cancer Inst","author":"Therasse P","year":"2000"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00973.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-62-740-679"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14361-9"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1740-8261.2012.01970.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1740-8261.2012.01970.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:45:09Z","timestamp":1748652309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1740-8261.2012.01970.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,19]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1740-8261.2012.01970.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1740-8261.2012.01970.x","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,19]]}}}