{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:56:35Z","timestamp":1775321795034,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,16]],"date-time":"2005-12-16T00:00:00Z","timestamp":1134691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early life factors and, in particular, the fetal environment have been suggested to programme risk of allergic disease in later life. Diversion of nutrients away from immune organs towards the brain, a process termed brain sparing, has been proposed as a mechanism underpinning this association. The study population was a group of 256 seven\u2010year old children from the UK recruited from two general practitioner surgeries. Historical anthropometric data from birth to age three and current anthropometry were assessed as predictors of parent\u2010reported wheeze and eczema. Eczema at seven years was not related to any anthropometric indices at birth or during infancy. A smaller head circumference at 10\u201315\u2003days of age was noted in children with current wheeze at age 7\u2003years (<jats:italic>P<\/jats:italic>\u2003=\u20030.018) and this relationship persisted after adjustment for current anthropometry and confounders. Comparison of children with head circumference over 36.5\u2003cm at 10\u201315\u2003days with those with head circumference under 35.5\u2003cm, showed reduced odds for wheeze at 7\u2003years (OR 0.12, 95% CI 0.03\u20130.44, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2003=\u20030.009).These data suggest that factors that determine fetal growth may be associated with wheeze in childhood and support the developmental origins of health and disease hypothesis. Brain sparing does not appear to play a role in this early life programming.<\/jats:p>","DOI":"10.1111\/j.1740-8709.2006.00036.x","type":"journal-article","created":{"date-parts":[[2005,12,16]],"date-time":"2005-12-16T10:56:08Z","timestamp":1134730568000},"page":"51-61","source":"Crossref","is-referenced-by-count":13,"title":["Wheezing and eczema in relation to infant anthropometry: evidence of developmental programming of disease in childhood"],"prefix":"10.1111","volume":"2","author":[{"given":"Lynda J.","family":"Carrington","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Langley\u2010Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.028s5052.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.3.225"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025388901248"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.259"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6804.671"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1992.tb00741.x"},{"key":"e_1_2_6_8_1","volume-title":"Child Development and Child Health","author":"Bax M.","year":"1990"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7123244"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01128.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01890.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(00)00190-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09718.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.4.327"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.6.1310"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1155\/1997\/872149","article-title":"Birthweight and preterm birth in relation to indicators of childhood asthma","volume":"4","author":"Demissie K.","year":"1997","journal-title":"Canadian Respiratory Journal"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13590849208997980"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.11.3006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-1012-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1997.1430947.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.90.1.20"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1994.tb00968.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb11911.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19980016"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7028.410"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00485.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/9780851998213.0000","volume-title":"Fetal Nutrition and Adult Disease: Programming of Chronic Disease through Fetal Exposure to Undernutrition","author":"Langley\u2010Evans S.C.","year":"2004"},{"key":"e_1_2_6_28_1","first-page":"121A","article-title":"Fetal exposure to a maternal low protein diet and the immune system","volume":"61","author":"Langley\u2010Evans S.C.","year":"2002","journal-title":"Proceedings of the Nutrition Society"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/146642400312300409"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/jn\/127.2.202","article-title":"Fetal exposure to a maternal low protein diet alters the susceptibility of the young adult rat to sulphur dioxide\u2010induced lung injury","volume":"127","author":"Langley\u2010Evans S.C.","year":"1997","journal-title":"Journal of Nutrition"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.10.905"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.7.555"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7206.339"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1225"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19980038"},{"key":"e_1_2_6_36_1","volume-title":"Standard Occupational Classification","author":"OPCS.","year":"1990"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050086"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1031"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.5.396"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(83)90081-4"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.10.895"},{"key":"e_1_2_6_42_1","volume-title":"Fetus into Man: Physical Growth from Conception to Maturity","author":"Tanner J.M.","year":"1989"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1740-8709.2006.00036.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:27:33Z","timestamp":1696969653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1740-8709.2006.00036.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,16]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1740-8709.2006.00036.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1740-8709.2006.00036.x","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"value":"1740-8695","type":"print"},{"value":"1740-8709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,16]]}}}