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Most of these intervention trials have involved infants from high\u2010income countries, and a significant proportion have investigated supplementation of infant formulas. Generally, supplementation of infant formula for preterm rather than term infants has demonstrated more consistent, positive effects on aspects of neurobehavioural development, while the growth of both term and preterm infants appears unaffected by LCPUFA supplementation. Maternal n\u20103 LCPUFA supplementation during pregnancy has consistently resulted in modest increases in birth size, and the most recent study suggests that this is also true from women from low\u2010income environments. The effect of maternal supplementation on global neurobehavioural outcomes for children born at term remains unclear, although n\u20103 LCPUFA supplementation of women expressing milk for their preterm infants does improve their performance on tests of global neurodevelopment. Further work is required to determine whether dietary n\u20103 LCPUFA is neuroprotective for children from disadvantaged or low\u2010income backgrounds.<\/jats:p>","DOI":"10.1111\/j.1740-8709.2011.00304.x","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T18:52:11Z","timestamp":1299351131000},"page":"80-88","source":"Crossref","is-referenced-by-count":69,"title":["Impact of fatty acid status on growth and neurobehavioural development in humans"],"prefix":"10.1111","volume":"7","author":[{"given":"Maria","family":"Makrides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel T.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.095745"},{"key":"e_1_2_9_3_1","first-page":"2365","article-title":"Retinal development in very\u2010low\u2010birth\u2010weight infants fed diets differing in omega\u20103 fatty acids","volume":"33","author":"Birch D.","year":"1992","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_9_4_1","first-page":"3242","article-title":"Dietary essential fatty acid supply and visual acuity development","volume":"33","author":"Birch E.","year":"1992","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2001.0093"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535870"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/58.1.35"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/ajcn\/63.5.687","article-title":"Effect of long\u2010chain n\u20103 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia","volume":"63","author":"Carlson S.E.","year":"1996","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.099085"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600446"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.108.5.e82","article-title":"Similar effects on infants of n\u20103 and n\u20106 fatty acids supplementation to pregnant and lactating women","volume":"108","author":"Helland I.B.","year":"2001","journal-title":"Pediatrics"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2762"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e39"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1511"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60277-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507709078"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819773cf"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.123282"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.06.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.125"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.6.1572"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2005044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000169978.92437.58"},{"key":"e_1_2_9_26_1","first-page":"CD003402","article-title":"Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre\u2010eclampsia or intrauterine growth restriction","volume":"3","author":"Makrides M.","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.945"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.5.1094"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1507"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000281154"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn034"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90055-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.39.1.27"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","unstructured":"RamakrishnanU. 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