{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:27Z","timestamp":1787015067361,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T00:00:00Z","timestamp":1107907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    To assess the efficacy of subantimicrobial dose doxycycline (SDD; 20\u2003mg doxycycline twice daily) as an adjunct to scaling and root planing (SRP) in the treatment of moderate\u2010severe chronic periodontitis (CP) in institutionalised elderly patients aged 65\u2003years or older.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Previous studies have shown that SDD is of clinical benefit in the treatment of CP. However, the benefits of SDD in geriatric populations (65+\u2003years) have not been determined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods:\u2002<\/jats:bold>\n                    A 9\u2010month, double\u2010blind, randomised, placebo\u2010controlled pilot study was conducted. 24 institutionalised geriatric patients (65\u2003years or older) with evidence of CP manifested by baseline clinical attachment levels (CAL) 5\u20139\u2003mm, probing depths (PD) 4\u20139\u2003mm and bleeding on probing (BOP) were recruited. At baseline, patients were treated by a standardised episode of SRP, and randomised to receive either adjunctive SDD or placebo. Full mouth PD and CAL were measured using the manual UNC\u201015 periodontal probe at 3, 6, and 9\u2003months post\u2010baseline to assess the response to treatment. Periodontal sites were stratified by baseline PD value: sites with PD 4\u20135\u2003mm were considered moderately diseased and sites with PD \u22656\u2003mm severely diseased.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    The SRP\u2003+\u2003placebo resulted in PD reductions similar to those reported previously in the literature. At all time\u2010points and in both moderate and deep sites, SRP\u2003+\u2003SDD resulted in significantly greater PD reductions relative to baseline than SRP\u2003+\u2003placebo. At month 9, in moderate sites, mean PD reductions of 1.57\u2003\u00b1\u20030.11\u2003mm were reported in the adjunctive SDD group, compared with 0.63\u2003\u00b1\u20030.11\u2003mm in the adjunctive placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003&lt;\u20030.001). In deep sites at month 9, mean PD reductions of 3.22\u2003\u00b1\u20030.29\u2003mm were reported in the adjunctive SDD group, compared with 0.98\u2003\u00b1\u20030.31\u2003mm in the adjunctive placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003&lt;\u20030.05). Similar improvements were observed for CAL in the SDD group compared with the placebo group. Significantly lower BOP scores were also recorded at month 9 in the SDD group (7.5%) compared with the placebo group (71.2%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003&lt;\u20030.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    SDD used as an adjunct to SRP provides significant benefit for elderly patients with CP compared with SRP alone.\n                  <\/jats:p>","DOI":"10.1111\/j.1741-2358.2004.00044.x","type":"journal-article","created":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T04:21:36Z","timestamp":1107922896000},"page":"37-43","source":"Crossref","is-referenced-by-count":27,"title":["Adjunctive subantimicrobial dose doxycycline in the management of institutionalised geriatric patients with chronic periodontitis*"],"prefix":"10.1111","volume":"22","author":[{"given":"Abdel R.","family":"Mohammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Preshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur F.","family":"Hefti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Powala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Romanowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,9]]},"reference":[{"key":"e_1_2_11_2_2","volume-title":"Clinician's Guide to Oral Health in Geriatric Patients. 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