{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:58:52Z","timestamp":1791302332546,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Denture base acrylic resin is easily colonised by oral endogenous bacteria and <jats:italic>Candida<\/jats:italic> spp., and eventually by extra\u2010oral species such as <jats:italic>Staphylococcus<\/jats:italic> spp., <jats:italic>Pseudomonadaceae<\/jats:italic> or members of <jats:italic>Enterobacteriaceae<\/jats:italic>. This microbial reservoir can be responsive for denture related stomatitis and aspiration pneumonia, a life\u2010threatening infection especially in geriatric patients. However, the oral and denture hygiene of dependant elderly individuals is extremely poor.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> This <jats:italic>in vitro<\/jats:italic> study aimed to determine the per cent of a quaternary ammonium compound heat\u2010polymerised in acrylic resin necessary to obtain denture base displaying antiseptic properties.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> Acrylic resin discs containing 2\u201350% ammonium polymer (Poly 202063A; 0% control) were soaked in artificial saliva for 4\u2003weeks. Resin discs were incubated for 24\u2003hours with <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic> [37\u00b0C, brain\u2013heart infusion (BHI) broth and phosphate\u2010buffered saline (PBS) buffer] and <jats:italic>Candida albicans<\/jats:italic> (30\u00b0C, Schaedler broth), in 15\u2003ml (168 discs) and 600\u2003<jats:italic>\u03bc<\/jats:italic>l (168 discs) of inoculum. Microbial growth was verified at <jats:italic>t<\/jats:italic> 0\u2003hours and <jats:italic>t<\/jats:italic> 24\u2003hours. Data were recorded as the mean of three colony forming unit (CFU) numerations. The borderline of antimicrobial effect was determined at 0.1% viable cells.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In 600\u2003<jats:italic>\u03bc<\/jats:italic>l of PBS inoculum, resin specimens had a bactericidal effect (<jats:italic>E. coli<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic>: 2%; <jats:italic>P. aeruginosa<\/jats:italic>: 10%) and a fungicidal effect (<jats:italic>C. albicans<\/jats:italic>: 50%). Long\u2010term stability and toxicity <jats:italic>in vivo<\/jats:italic> studies are now required.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> A 2% quaternary ammonium compound polymerised with a denture acrylic resin displayed antiseptic properties after a 4\u2010week soaking period in artificial saliva. Such antiseptic denture base could help geriatric patients to improve their oral health.<\/jats:p>","DOI":"10.1111\/j.1741-2358.2006.00088.x","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T14:45:37Z","timestamp":1146840337000},"page":"111-116","source":"Crossref","is-referenced-by-count":45,"title":["<i>In vitro<\/i> antiseptic properties of an ammonium compound combined with denture base acrylic 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