{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:50Z","timestamp":1787015030251,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T00:00:00Z","timestamp":1332892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    <jats:italic>doi: 10.1111\/j.1741\u20102358.2012.00660.x<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Periodontitis and Alzheimer\u2019s disease: Oral systemic link still on the rise?<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>Over the past few years, there has been a rapid rise in the older segments of the world population, which has brought along with it a major health concern: dementia. Alzheimer\u2019s disease, considered to be the most common cause of dementia, has become a prospect feared by the elderly. Inflammation of the brain is strongly implicated in Alzheimer\u2019s disease which could be enhanced by systemic inflammation. Periodontitis being a chronic inflammatory condition, which can cause systemic inflammation, the question is whether chronic periodontitis can initiate or hasten the rate of progression of Alzheimer\u2019s disease in susceptible individuals. In this article, the authors outline the proposed oral systemic link between periodontitis and Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1111\/j.1741-2358.2012.00660.x","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T13:53:30Z","timestamp":1333115610000},"page":"239-242","source":"Crossref","is-referenced-by-count":23,"title":["Periodontitis and Alzheimer\u2019s disease: oral systemic link still on the rise?"],"prefix":"10.1111","volume":"30","author":[{"given":"Ashita S.","family":"Uppoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima S.","family":"Lohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,28]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1856","volume-title":"Neurology in Clinical Practice","author":"Dekosky ST","year":"2008"},{"key":"e_1_2_8_3_2","first-page":"633","volume-title":"Merritt\u2019s Neurology","author":"Small SA","year":"2000"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S3610"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-13408"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00924.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.1007"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2001.00100.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00086-6"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071472"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00136.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2005.11.003"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi000029f"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000095973.42032.44"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150886.50187.30"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.t01-1-261101.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04008-3"},{"key":"e_1_2_8_22_2","first-page":"173","article-title":"Alzheimer\u2019s disease, herpes virus in brain, apolipoprotein e4 and herpes labialis","volume":"1","author":"Lin WR","year":"1998","journal-title":"Alzheimers Rep"}],"container-title":["Gerodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1741-2358.2012.00660.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1741-2358.2012.00660.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:05:40Z","timestamp":1696205140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1741-2358.2012.00660.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,28]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/j.1741-2358.2012.00660.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1741-2358.2012.00660.x","archive":["Portico"],"relation":{},"ISSN":["0734-0664","1741-2358"],"issn-type":[{"value":"0734-0664","type":"print"},{"value":"1741-2358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,28]]}}}