{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:07:56Z","timestamp":1764781676924},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>ABSTRACT\u2003<\/jats:bold> DDT, an organochlorine pesticide, has been cited as a representative chemical suspected of having endocrine disrupting effects. In this study, the potential endocrine disrupting activities of <jats:italic>p,p\u2032<\/jats:italic>\u2010DDT, a major component of DDT, were investigated in rats in a 2\u2010generation reproduction toxicity study in accordance with the most current test guidelines of the Ministry of Agriculture, Forestry and Fisheries in Japan, Organization for Economic Cooperation and Development (OECD) and United States Environmental Protection Agency (USEPA) with some modifications and additions. <jats:italic>p,p\u2032<\/jats:italic>\u2010DDT was given to parental rats at dietary levels of 0, 5, 50 or 350\u2003ppm. Systemic toxicities in the parental animals consisted of tremors and subsequent deaths (females only) and\/or pathological alterations of the liver (both sexes of animals) of the 2 higher dose groups. Reproductive and postnatal developmental toxicities were not evident up to the highest dose level except for the decreased pup viability index on postnatal day 21 in the 350\u2003ppm group. Changes in serum estradiol and progesterone levels and\/or a delay in male sexual maturation were noted in the 2 higher dose groups in a dose\u2010dependent fashion, suggesting alterations of endogenous endocrine functions. However, these changes never resulted in substantial reproductive disorders.<\/jats:p>","DOI":"10.1111\/j.1741-4520.2006.00110.x","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T16:23:20Z","timestamp":1148660600000},"page":"105-114","source":"Crossref","is-referenced-by-count":14,"title":["Two\u2010generation reproduction toxicity study in rats with 1,1,1\u2010trichloro\u20102,2\u2010<i>bis<\/i>(4\u2010chlorophenyl)ethane (<i>p,p\u2032<\/i>\u2010DDT)"],"prefix":"10.1111","volume":"46","author":[{"given":"Hitoshi","family":"Hojo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken L.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sakasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Saka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00354089"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac200375112497"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00893.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.30.S59"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106551"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(62)90078-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg105"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2003.10.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.3.248"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.94102680"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390173941"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb07199.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00858.x"},{"key":"e_1_2_6_16_1","unstructured":"International POPs Elimination Network (IPEN) Pesticide Working Group(2002) DDT & Malaria: Answers to common question. 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