{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:13:18Z","timestamp":1758705198489},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>ABSTRACT\u2003<\/jats:bold>It is well known that ochratoxin A (OTA) induces neural tube defects (NTDs) in mice. In the present study, OTA was administered to the genetic polydactyly\/arhinencephaly mouse (<jats:italic>Pdn\/Pdn<\/jats:italic>) to investigate the synergistic effect between gene and environmental toxin. OTA treatment on day 7.5 of gestation increased NTDs in the<jats:italic>Pdn\/Pdn<\/jats:italic>mouse. The responsible gene for<jats:italic>Pdn\/Pdn<\/jats:italic>is<jats:italic>Gli3<\/jats:italic>. So, it was speculated that specific susceptibility for OTA in the<jats:italic>Pdn\/Pdn<\/jats:italic>mouse embryo may be due to the severe depression of<jats:italic>Gli3<\/jats:italic>gene expression. As correlated genes,<jats:italic>Gli3<\/jats:italic>,<jats:italic>Shh<\/jats:italic>and<jats:italic>Fgf8<\/jats:italic>gene expressions were examined in the<jats:italic>Pdn<\/jats:italic>mouse embryo on day 9 of gestation after administration of OTA on day 7.5. No alteration of<jats:italic>Shh<\/jats:italic>expression was observed in the non\u2010treated<jats:italic>Pdn\/Pdn<\/jats:italic>, and OTA\u2010treated +\/+ and<jats:italic>Pdn\/Pdn<\/jats:italic>.<jats:italic>Fgf8<\/jats:italic>signal was observed at the anterior neural ridge (ANR) in the non\u2010treated +\/+, and that was elongated in the non\u2010treated<jats:italic>Pdn\/Pdn<\/jats:italic>, and further elongated and more intensive in the OTA\u2010treated<jats:italic>Pdn\/Pdn<\/jats:italic>. It was suggested that<jats:italic>Fgf8<\/jats:italic>gene expression was affected by the depression of<jats:italic>Gli3<\/jats:italic>, and alteration of<jats:italic>Fgf8<\/jats:italic>gene expression was accelerated by the toxicity of OTA in the<jats:italic>Pdn\/Pdn.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1741-4520.2006.00117.x","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T09:53:32Z","timestamp":1155894812000},"page":"144-148","source":"Crossref","is-referenced-by-count":9,"title":["Genetic susceptibility in the neural tube defects induced by ochratoxin A in the genetic arhinencephaly mouse,<i>Pdn\/Pdn<\/i>"],"prefix":"10.1111","volume":"46","author":[{"given":"Ken\u2010ichi","family":"Ohta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuho","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu\u2010ichi","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0811"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050594"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(76)90096-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-7189(199809\/10)6:5<173::AID-NT10>3.0.CO;2-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2003.tb01022.x"},{"key":"e_1_2_6_7_1","first-page":"162","article-title":"Common hierarchies of susceptiblility to teratogen\u2010induced neural tube defects in the mouse","volume":"5","author":"Finnell RH","year":"1985","journal-title":"Proc Grnwd Genet Ctr"},{"key":"e_1_2_6_8_1","first-page":"189","article-title":"Oxycephaly","volume":"33","author":"Greig DM","year":"1926","journal-title":"Edin Med J"},{"key":"e_1_2_6_9_1","first-page":"391","article-title":"Polydactyly Nagoya, Pdn: A new mutant gene in the mouse","volume":"29","author":"Hayasaka I","year":"1980","journal-title":"Jikkenn Dobutu (Exp Anim)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014282"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130103"},{"key":"e_1_2_6_12_1","first-page":"4884","article-title":"A disrupted balance between Bmp\/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon","volume":"260","author":"Kushels S","year":"2003","journal-title":"Dev Biol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/79916"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01033"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1242\/dev.126.21.4827","article-title":"Fgf8 can activate Gbx2 and transform regions of the rostral mouse brain into hindbrain fate","volume":"126","author":"Liu A","year":"1999","journal-title":"Development"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2005.00082.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90028-2"},{"key":"e_1_2_6_19_1","first-page":"137","article-title":"Morphogenesis of genetic preaxial polydactyly, Polydactyly Nagoya, Pdn, in mice","volume":"22","author":"Naruse I","year":"1982","journal-title":"Congenit Anom Kyoto"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)00024-P"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00851.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380113"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90283-5"},{"key":"e_1_2_6_24_1","first-page":"S25","article-title":"Mechanism of polydactyly manifestation in mice and its extrapolation to humans","volume":"40","author":"Naruse I","year":"2000","journal-title":"Congenit Anom Kyoto"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2001.tb00819.x"},{"key":"e_1_2_6_26_1","first-page":"83","article-title":"Molecular analyses in the mouse homolog of Greig cephalopolysyndactyly syndrome (GCPS)","volume":"1","author":"Naruse I","year":"2005","journal-title":"Trend Dev Biol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440590905948"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb26106.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900973"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00898.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2003.00005.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/352539a0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00356157"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80678-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20021"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20022"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199606)53:6<378::AID-TERA9>3.0.CO;2-W"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1979"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oso\/9780199636594.003.0004","volume-title":"In situ Hybridization: a Practical Approach","author":"Xu Q","year":"1998"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1741-4520.2006.00117.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1741-4520.2006.00117.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T01:23:13Z","timestamp":1707182593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1741-4520.2006.00117.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,18]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1741-4520.2006.00117.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1741-4520.2006.00117.x","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,18]]}}}