{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:30:06Z","timestamp":1778884206042,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>ABSTRACT\u2003<\/jats:bold> The purpose of this study was to examine the clinical features of pregnancy complicated by polyhydramnios associated with fetal anomalies. Sixty\u2010nine patients with a singleton pregnancy complicated by polyhydramnios were retrospectively analyzed. Based on prenatal ultrasonographic findings, 13\u2003cases were considered to have idiopathic polyhydramnios and the remaining 56\u2003cases were associated with fetal anomalies. Between these two groups, no significant difference was found in the gestational weeks when polyhydramnios developed. However, significant difference was noted in the maximum amniotic fluid index (AFI) values during the pregnancy period; 25.4\u2003\u00b1\u20032.7\u2003cm in the former, and 30.6\u2003\u00b1\u20038.9\u2003cm in the latter (<jats:italic>P<\/jats:italic>\u2003=\u20030.0004). In all of 13 cases with idiopathic polyhydramnios, AFI values remained less than 30\u2003cm until delivery. Twenty\u2010two patients (39%) with fetal anomalies required a prenatal treatment such as amnioreduction and tocolysis, whereas only one patient (7.7%) with idiopathic polyhydramnios needed tocolysis therapy (<jats:italic>P<\/jats:italic>\u2003=\u20030.03). There was a significant risk of premature delivery with fetal anomalies (35.6\u2003\u00b1\u20033.9\u2003weeks\u2019 gestation vs. 38.8\u2003\u00b1\u20031.5\u2003weeks\u2019 gestation, <jats:italic>P<\/jats:italic>\u2003=\u20030.004) because of refractory polyhydramnios, rupture of membranes, non\u2010reassuring fetal status, and intrauterine fetal death, and although most infants with idiopathic polyhydramnios were appropriate\u2010for\u2010dates, many of the infants with congenital anomalies were small\u2010for\u2010dates. Significant risk of fetal anomalies should be considered in pregnant women with severe polyhydramnios (AFI\u2003\u2265\u200330\u2003cm), an increased trend of amniotic fluid during the pregnancy period, polyhydramnios requiring a prenatal treatment, or fetal growth restriction. On the other hand, based on our experience, a fetus without these conditions seems to have a low risk of congenital anomalies even if polyhydramnios is noted.<\/jats:p>","DOI":"10.1111\/j.1741-4520.2006.00125.x","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T10:21:19Z","timestamp":1163067679000},"page":"177-179","source":"Crossref","is-referenced-by-count":10,"title":["Clinical features of polyhydramnios associated with fetal anomalies"],"prefix":"10.1111","volume":"46","author":[{"given":"Kikue","family":"Hara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Miyachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorahiro","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiyo","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90643-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90058-F"},{"key":"e_1_2_5_4_1","volume-title":"FETOLOGY: Diagnosis & Management of the Fetal Patient","author":"Bianchi DW","year":"2000"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90527-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198710000-00001"},{"key":"e_1_2_5_7_1","first-page":"989","article-title":"Quantifiable polyhydramnios: Diagnosis and management","volume":"75","author":"Carlson DE","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90360-0"},{"key":"e_1_2_5_9_1","first-page":"813","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2001"},{"key":"e_1_2_5_10_1","first-page":"21","article-title":"Polyhydramnios: Ultrasonically detected prevalence and neonatal outcome","volume":"69","author":"Hill LM","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_11_1","first-page":"89","article-title":"Clinico\u2010pathological analysis of 39 autopsy cases with lethal osteochondrogenesis","volume":"12","author":"Kinoshita N","year":"2000","journal-title":"Nippon Mijukuji Shinseiji Gakkai Zasshi"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80358-7"},{"key":"e_1_2_5_13_1","first-page":"94","article-title":"Mechanisms of production and clearance of amniotic fluid","volume":"10","author":"Lotgering FK","year":"1986","journal-title":"Semin Perinatol"},{"key":"e_1_2_5_14_1","first-page":"511","article-title":"Clinical studies of hydramnios in the measurements of the amniotic fluid index by ultrasound","volume":"35","author":"Makino Y","year":"1999","journal-title":"Nippon Shinseiji Gakkai Zasshi"},{"key":"e_1_2_5_15_1","first-page":"197","article-title":"Polyhydramnios: Problems and treatment","volume":"17","author":"Moise KJ","year":"1993","journal-title":"Semin Perinatol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199706000-00004"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90009-V"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00404-002-0353-0","article-title":"Incidence of fetal malformations in pregnancies complicated by oligo\u2010 and polyhydramnios","volume":"268","author":"Pauer HU","year":"2003","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30616-X"},{"key":"e_1_2_5_20_1","first-page":"540","article-title":"Amniotic fluid volume assessment with the four\u2010quadrant technique at 36\u201342\u2003weeks\u2019 gestation","volume":"32","author":"Phelan JP","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_5_21_1","first-page":"233","article-title":"The amniotic fluid. 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