{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:41:20Z","timestamp":1697434880962},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>ABSTRACT\u2003<\/jats:bold> Erythropoietin, by binding to its receptor, stimulates definitive erythroblasts to accumulate hemoglobin (Hb) by up\u2010regulating erythroid\u2010specific genes and causes differentiation of erythroblasts into erythrocytes. In mouse decidua we have found the expression of transcripts for the erythropoietin receptor, the function of which has not yet been elucidated. Erythropoietin signaling was inhibited by the injection of a soluble form of the erythropoietin receptor capable of binding with erythropoietin into the mouse uterine cavity on day\u20034 of gestation, and pale and defective decidual bodies appeared three days later. These pale decidual bodies contained defective embryos without extension to the ectoplacental region, while normal reddish decidual bodies contained normal developing embryos and expressed embryonic and adult Hb with characteristic location of the respective hemoglobins in which an \u025b\u2010 or \u03b2\u2010globin signal was confirmed. Furthermore, blocking of erythropoietin signaling destroyed Hb\u2010containing cells and resulted in apoptosis that caused embryonic death. Thus, erythropoietin\u2010mediated Hb synthesis is essential for the survival of decidual cells. In addition, although no transcripts for GATA\u20101 and erythroid heme enzymes could be detected, genes for \u03b2\u2010globin, as well as non\u2010specific \u03b4\u2010aminolevulinate synthase, were expressed and regulated in an erythropoietin\u2010dependent manner. This is the first evidence that ectopic Hb synthesis exists and that erythropoietin coregulates erythroid (globin) and nonerythroid (\u03b4\u2010aminolevulinate synthase) genes.<\/jats:p>","DOI":"10.1111\/j.1741-4520.2006.00137.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T23:51:19Z","timestamp":1171410679000},"page":"22-33","source":"Crossref","is-referenced-by-count":5,"title":["Erythropoietin contributes to implantation: Ectopic hemoglobin synthesis in decidual cells of mice"],"prefix":"10.1111","volume":"47","author":[{"given":"Yoshiko","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyo","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/362722a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-364932-4.50010-1"},{"key":"e_1_2_6_4_1","first-page":"293","article-title":"The erythropoietin receptor and the molecular basis of signal transduction","volume":"29","author":"Barber DL","year":"1992","journal-title":"Semin Hematol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051980308"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.4.607"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1983.2.329"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.7.8635693"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3717"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.6.1095"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V40.5.671.671"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(84)90087-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb00297.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(91)90195-R"},{"key":"e_1_2_6_15_1","first-page":"17494","article-title":"Erythroleukemia differentiation","volume":"266","author":"Fujita H","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.493"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080330103"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.4.1108"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"9215","DOI":"10.1016\/S0021-9258(19)40633-9","article-title":"Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition","volume":"250","author":"Granick S","year":"1975","journal-title":"J Biol Chem"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.7.2335"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0021-9258(19)68306-7","article-title":"The sequence of a mouse embryonic \u03b2\u2010globin gene. 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