{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:54:42Z","timestamp":1763765682825},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T00:00:00Z","timestamp":1186444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>ABSTRACT\u2003<\/jats:bold> A hypothesis is presented that the association between maternal influenza and other causes of fever during the second trimester of pregnancy and the subsequent development of schizophrenia in the child is due to the damage caused by hyperthermia to the developing amygdalohippocampal complex and associated structures in the fetal brain. Hyperthermia is a known cause of congenital defects of the central nervous system and other organs after sufficiently severe exposures during early organogenesis. The pathogenic mechanisms include death of actively dividing neuroblasts, disruption of cell migration and arborization and vascular damage. In experimental studies, hyperthermia during later stages of central nervous system development also caused damage to the developing brainstem that was associated with functional defects. This damage usually results in hypoplasia of the parts undergoing active development at the time of exposure. Recent studies have shown no evidence of direct invasion of the fetus by the influenza virus. Factors that might interact with hyperthermia include familial liability to schizophrenia, season of birth, maternal nutrition, severe stress and medications used to alleviate the symptoms of fevers. The time of the development of the fetal amygdalohippocampal complex and the changes found in its structure and associated areas of the brain are compatible with the known effects of hyperthermia.<\/jats:p>","DOI":"10.1111\/j.1741-4520.2007.00151.x","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T08:00:37Z","timestamp":1186473637000},"page":"84-89","source":"Crossref","is-referenced-by-count":30,"title":["Hyperthermia <i>in utero<\/i> due to maternal influenza is an environmental risk factor for schizophrenia"],"prefix":"10.1111","volume":"47","author":[{"given":"Marshall J.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10130"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.163.4.522"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2.1.53"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbj052"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.8.774"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033453"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199812)58:6<251::AID-TERA6>3.0.CO;2-L"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbj028"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/258604a0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170306"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)91585-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)91567-8"},{"key":"e_1_2_6_14_1","first-page":"55","volume-title":"Birth Defects: New Research.","author":"Czeizel AE","year":"2006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.10.757"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10096"},{"key":"e_1_2_6_17_1","first-page":"42","article-title":"Congenital defects in guinea\u2010pigs following induced hyperthermia during gestation","volume":"84","author":"Edwards MJ","year":"1967","journal-title":"Arch Pathol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020406"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020407"},{"key":"e_1_2_6_20_1","first-page":"335","volume-title":"Fetal Brain Disorders \u2013 Recent Approaches to the Problem of Mental Deficiency","author":"Edwards M","year":"1981"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060610"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290217"},{"key":"e_1_2_6_23_1","first-page":"593","article-title":"Mitotic cell death and delay of mitotic activity in guinea\u2010pig embryos following brief maternal hyperthermia","volume":"32","author":"Edwards MJ","year":"1974","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265673021000039628"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(95)00043-A"},{"key":"e_1_2_6_26_1","first-page":"345","article-title":"Hyperthermia, teratogenesis and the heat shock response in mammalian embryos in culture","volume":"41","author":"Edwards MJ","year":"1997","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1976.tb00518.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420430106"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.12.007"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330213"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20185"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199811)58:5<209::AID-TERA8>3.0.CO;2-Q"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.033"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00295-4"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90306-7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11621.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(76)90056-3"},{"key":"e_1_2_6_38_1","first-page":"525","article-title":"Embryology of the human fetal hippocampus: MR imaging, anatomy, and histology","volume":"18","author":"Kier EL","year":"1997","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00396-7"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2003.00052.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-7552(77)90036-5"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20100"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00052-3"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00435-8"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.4.517"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2004.01.003"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199709)56:3<210::AID-TERA4>3.0.CO;2-4"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460315"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000152903.55579.15"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00698785"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300211"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92919-S"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.172.4.324"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(92)90006-P"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.11.005"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1980.tb04363.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.05.005"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242981"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.5.557"},{"key":"e_1_2_6_60_1","first-page":"455","article-title":"Structural MRI of the brain in presumed carriers of genes for schizophrenia, their affected and unaffected siblings","volume":"72","author":"Steel RM","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_6_61_1","first-page":"175","article-title":"Pregnancy infections in mothers of chronic schizophrenic patients. The significance of differential nosology","volume":"65","author":"Stober G","year":"1994","journal-title":"Nervenarzt"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20077"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120071010"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02191805"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80012-4"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07068.x"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390209"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20188"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400404"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020140207"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711180406"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.131"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1741-4520.2007.00151.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1741-4520.2007.00151.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:16:48Z","timestamp":1696972608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1741-4520.2007.00151.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,7]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1741-4520.2007.00151.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1741-4520.2007.00151.x","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,7]]}}}