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Here, we examined the array of post\u2010translational modifications imposed on the PTPRR protein isoforms PTPBR7, PTP\u2010SL, PTPPBS\u03b342 and PTPPBS\u03b337, which have distinct N\u2010terminal segments and localize to different parts of the cell. All isoforms were found to be short\u2010lived, constitutively phosphorylated proteins. In addition, the transmembrane isoform, PTPBR7, was subject to N\u2010terminal proteolytic processing, in between amino acid position 136 and 137, resulting in an additional, 65\u2010kDa transmembrane PTPRR isoform. Unlike for some other receptor\u2010type PTPs, the proteolytically produced N\u2010terminal ectodomain does not remain associated with this PTPRR\u201065. Shedding of PTPBR7\u2010derived polypeptides at the cell surface further adds to the molecular complexity of PTPRR biology.<\/jats:p>","DOI":"10.1111\/j.1742-4658.2006.05568.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T20:27:49Z","timestamp":1164659269000},"page":"96-108","source":"Crossref","is-referenced-by-count":8,"title":["Proteolytic processing of the receptor\u2010type protein tyrosine phosphatase PTPBR7"],"prefix":"10.1111","volume":"274","author":[{"given":"G\u00f6n\u00fcl","family":"Dilaver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinske","family":"van de Vorstenbosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"T\u00e1rrega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"R\u00edos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlijn","family":"van Aerde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiljan","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.51.61"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3123-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.21.7117-7136.2001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.018"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-24-07821.1996"},{"key":"e_1_2_7_7_2","first-page":"337","article-title":"STEP: a family of brain\u2010enriched PTPs. 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