{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:41:22Z","timestamp":1792734082487,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    <jats:italic>Helicobacter\u2003pylori<\/jats:italic>\n                    is a very successful human\u2010specific bacterium worldwide. Infections of the stomach with this pathogen can induce pathologies, including chronic gastritis, peptic ulcers and even gastric cancer. Highly virulent\n                    <jats:italic>H.\u2003pylori<\/jats:italic>\n                    strains encode the\n                    <jats:italic>cytotoxin\u2010associated gene<\/jats:italic>\n                    (\n                    <jats:italic>cag<\/jats:italic>\n                    )\u2010pathogenicity island, which expresses a type IV secretion system (T4SS). This T4SS forms a syringe\u2010like pilus structure for the injection of virulence factors such as the CagA effector protein into host target cells. This is achieved by a number of T4SS proteins, including CagI, CagL, CagY and CagA, which by itself binds the host cell integrin member \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    followed by delivery of CagA across the host cell membrane. A role of CagA interaction with phosphatidylserine has also been shown to be important for the injection process. After delivery, CagA becomes phosphorylated by oncogenic tyrosine kinases and mimics a host cell factor for the activation or inactivation of some specific intracellular signalling pathways. We review recent progress aiming to characterize the CagA\u2010dependent and CagA\u2010independent signalling capabilities of the T4SS, which include the induction of membrane dynamics, disruption of cell\u2013cell junctions and actin\u2010cytoskeletal rearrangements, as well as pro\u2010inflammatory, cell cycle\u2010related and anti\u2010apoptotic transcriptional responses. The contribution of these signalling pathways to pathogenesis during\n                    <jats:italic>H.\u2003pylori<\/jats:italic>\n                    infections is discussed.\n                  <\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08035.x","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T09:43:27Z","timestamp":1296553407000},"page":"1190-1202","source":"Crossref","is-referenced-by-count":218,"title":["Role of the\n                    <i>cag<\/i>\n                    \u2010pathogenicity island encoded type IV secretion system in\n                    <i>Helicobacter\u2003pylori<\/i>\n                    pathogenesis"],"prefix":"10.1111","volume":"278","author":[{"given":"Nicole","family":"Tegtmeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Wessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Backert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1868"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.009"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38605"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001069"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1131"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01156.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.12.003"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.114"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.08.003"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03549.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06187"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01341-07"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000684"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.04.005"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.05.005"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1601"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.064"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504927102"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711183105"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02089.x"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.4.8.10217"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1566"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200208039"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107630200"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.096214"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00759.x"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.005"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.304"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/604727"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801818200"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-4658.2011.08035.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2011.08035.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:24:41Z","timestamp":1696652681000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-4658.2011.08035.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,25]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1742-4658.2011.08035.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08035.x","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,25]]}}}