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Efficient induction of antigen\u2010specific cytotoxic T lymphocytes is important for immunological suppression of virus\u2010infected cell proliferation and oncogenesis, but efficient induction of antigen\u2010specific cytotoxic T lymphocytes has evaded strategies utilizing poorly immunogenic free synthetic peptides. Here, we examined the efficient induction of an HTLV\u20101\u2010specific CD8+ T\u2010cell response by oligomannose\u2010coated liposomes (OMLs) encapsulating the human leukocyte antigen (HLA)\u2010A*0201\u2010restricted HTLV\u20101 Tax\u2010epitope (OML\/Tax). Immunization of HLA\u2010A*0201 transgenic mice with OML\/Tax induced an HTLV\u20101\u2010specific gamma\u2010interferon reaction, whereas immunization with epitope peptide alone induced no reaction. Upon exposure of dendritic cells to OML\/Tax, the levels of CD86, major histocompatibility complex class I, HLA\u2010A02 and major histocompatibility complex class II expression were increased. In addition, our results showed that HTLV\u20101\u2010specific CD8+ T cells can be efficiently induced by OML\/Tax from HTLV\u20101 carriers compared with epitope peptide alone, and these HTLV\u20101\u2010specific CD8+ T cells were able to lyse cells presenting the peptide. These results suggest that OML\/Tax is capable of inducing antigen\u2010specific cellular immune responses without adjuvants and may be useful as an effective vaccine carrier for prophylaxis in tumors and infectious diseases by substituting the epitope peptide.<\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08055.x","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T15:39:19Z","timestamp":1298129959000},"page":"1358-1366","source":"Crossref","is-referenced-by-count":22,"title":["Oligomannose\u2010coated liposomes efficiently induce human T\u2010cell leukemia virus\u20101\u2010specific cytotoxic T lymphocytes without 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