{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:04:34Z","timestamp":1790075074360,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:00:00Z","timestamp":1300752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    Importin\u2003\u03b1 mediates the nuclear import of proteins through nuclear pore complexes in eukaryotic cells, and is common to all eukaryotes. Previous reports identified at least six importin\u2003\u03b1 family genes in mice. Although these isoforms show differential binding to various import cargoes\n                    <jats:italic>in\u2003vitro<\/jats:italic>\n                    , the\n                    <jats:italic>in\u2003vivo<\/jats:italic>\n                    physiological roles of these mammalian importin\u2003\u03b1 isoforms remain unknown. Here, we generated and examined importin\u2003\u03b15 knockout (\n                    <jats:italic>imp\u03b15<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice. These mice developed normally, and showed no gross histological abnormalities in most major organs. However, the ovary and uterus of\n                    <jats:italic>imp\u03b15<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    female mice exhibited hypoplasia. Furthermore, we found that\n                    <jats:italic>imp\u03b15<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    female mice had a 50% decrease in serum progesterone levels and a 57% decrease in progesterone receptor mRNA levels in the ovary. Additionally,\n                    <jats:italic>imp\u03b15<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    uteruses that were treated with exogenous gonadotropins displayed hypertrophy, similarly to progesterone receptor\u2010deficient mice. Although these mutant female mice could become pregnant, the total number of pups was significantly decreased, and some of the pups were dead at birth. These results suggest that importin\u2003\u03b15 has essential roles in the mammalian female reproductive organs.\n                  <\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08079.x","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T03:30:28Z","timestamp":1299209428000},"page":"1561-1572","source":"Crossref","is-referenced-by-count":21,"title":["Targeted disruption of one of the importin\u2003\u03b1 family members leads to female functional incompetence in 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