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Gain\u2010 and loss\u2010of\u2010function studies using <jats:italic>in\u2003vitro<\/jats:italic> and <jats:italic>in\u2003vivo<\/jats:italic> models have revealed distinct roles for specific miRNAs in cardiovascular development and physiological function. The implications of miRNAs in cardiovascular disease have recently been recognized, representing the most rapidly evolving research field. 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