{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:16:42Z","timestamp":1793362602624,"version":"4.5.0"},"reference-count":243,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T00:00:00Z","timestamp":1305590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    Snake venoms are cocktails of enzymes and non\u2010enzymatic proteins used for both the immobilization and digestion of prey. The most common snake venom enzymes include acetylcholinesterases,\n                    <jats:sc>l<\/jats:sc>\n                    \u2010amino acid oxidases, serine proteinases, metalloproteinases and phospholipases A\n                    <jats:sub>2<\/jats:sub>\n                    . Higher catalytic efficiency, thermal stability and resistance to proteolysis make these enzymes attractive models for biochemists, enzymologists and structural biologists. Here, we review the structures of these enzymes and describe their structure\u2010based mechanisms of catalysis and inhibition. Some of the enzymes exist as protein complexes in the venom. Thus we also discuss the functional role of non\u2010enzymatic subunits and the pharmacological effects of such protein complexes. The structures of inhibitor\u2013enzyme complexes provide ideal platforms for the design of potent inhibitors which are useful in the development of prototypes and lead compounds with potential therapeutic applications.\n                  <\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08115.x","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T10:47:51Z","timestamp":1302086871000},"page":"4544-4576","source":"Crossref","is-referenced-by-count":261,"title":["Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis"],"prefix":"10.1111","volume":"278","author":[{"given":"Tse Siang","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dessislava","family":"Georgieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Genov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio T.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mau","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy P.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Vrielink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Betzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuvir K.","family":"Arni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Manjunatha","family":"Kini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,17]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00148-2"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00490-X"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(97)00009-5"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.07.019"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00349a019"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35109-8"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64073-6"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.6.2546"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90040-Y"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(98)80007-7"},{"key":"e_1_2_13_12_2","first-page":"51","article-title":"Choline esterase in cobra venom","volume":"7","author":"Lyenger NK","year":"1938","journal-title":"Curr Sci India"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1973.tb02799.x"},{"key":"e_1_2_13_14_2","first-page":"459","article-title":"Enzymes of snake venoms and their biological significance","volume":"8","author":"Zeller EA","year":"1948","journal-title":"Adv Enzymol"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12241.x"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00447-4"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9812"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1678899"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.34.040194.001433"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37371-4"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.5.2082"},{"key":"e_1_2_13_22_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0026-895X(25)09933-X","article-title":"Differential effects of \u2018peripheral\u2019 site ligands on Torpedo and chicken acetylcholinesterase","volume":"45","author":"Eichler J","year":"1994","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_23_2","first-page":"207","volume-title":"Handbook of Venoms and Toxins of Reptiles","author":"Ahmed M","year":"2009"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1093-3263(98)00005-9"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.10.066"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.035"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00096a018"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90128-0"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.12.004"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.06.004"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.09.003"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.04.013"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1401"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00363-08"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07103.x"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240732"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167283"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86128-8"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(78)90165-1"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01160707"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00832a015"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(68)90275-1"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96172-7"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00869a019"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(51)90125-7"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(51)90126-9"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(51)90127-0"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93476-9"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.16.4204"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409237509102554"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(74)90523-3"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/273443a0"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.09.032"},{"key":"e_1_2_13_54_2","first-page":"567","volume-title":"Flavins and Flavoproteins","author":"Umhau S","year":"1999"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904000046"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.11.071"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800366200"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657280"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00133-7"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(00)00229-6"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(94)90407-3"},{"key":"e_1_2_13_62_2","first-page":"345","article-title":"l\u2010Amino acid oxidase from Trimeresurus jerdonii snake venom: purification, characterization, platelet aggregation\u2010inducing and antibacterial effects","volume":"11","author":"Lu QM","year":"2002","journal-title":"J Nat Toxins"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.03.049"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1023"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0996"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9539"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-7959-9"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022287"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00102-2"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02321.x"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-008-6132-9"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00020-5"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.3.175"},{"key":"e_1_2_13_74_2","volume-title":"Handbook of Lipid Research","author":"Waite M","year":"1987"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800033-JLR200"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.07.011"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40140-2"},{"key":"e_1_2_13_78_2","first-page":"1","volume-title":"Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism","author":"Kini RM","year":"1997"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060302"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.08.020"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03787.x"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04047.x"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(85)90004-2"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1.1986.5.519"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00105-0"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)97163-S"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a122815"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr990139w"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi7015102"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18711"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.003253"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2005.07.020"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00473-4"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206130200"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0258593"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444901014524"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3537"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.1.342"},{"key":"e_1_2_13_99_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444901018170"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.08.008"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1107\/S090744490302208X"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04547.x"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00853-3"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4550"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.041115505"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1987"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02833-4"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444903014598"},{"key":"e_1_2_13_109_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20708"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.12.1280"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000051701.90972.E5"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444901013543"},{"key":"e_1_2_13_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/352079a0"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm960502g"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902013720"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200390029"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021982"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0695-458"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948070"},{"key":"e_1_2_13_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20970"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444906003660"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.960"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/343694a0"},{"key":"e_1_2_13_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80744-8"},{"key":"e_1_2_13_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(00)01183-1"},{"key":"e_1_2_13_126_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2274785"},{"key":"e_1_2_13_127_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0483561"},{"key":"e_1_2_13_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2005.12.014"},{"key":"e_1_2_13_129_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00346a005"},{"key":"e_1_2_13_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(91)90132-6"},{"key":"e_1_2_13_131_2","first-page":"231","article-title":"Crotoxin: a possible mechanism of action","volume":"3","author":"Bon C","year":"1979","journal-title":"Adv Cytopharmacol"},{"key":"e_1_2_13_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb19869.x"},{"key":"e_1_2_13_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(76)90065-9"},{"key":"e_1_2_13_134_2","first-page":"269","volume-title":"Venom Phospholipase A2: Structure, Function and Mechanism","author":"Bon C","year":"1997"},{"key":"e_1_2_13_135_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309107006719"},{"key":"e_1_2_13_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(93)81395-X"},{"key":"e_1_2_13_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21980"},{"key":"e_1_2_13_138_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040125"},{"key":"e_1_2_13_139_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb07031.x"},{"key":"e_1_2_13_140_2","volume-title":"True Vipers: Natural History and Toxinology of Old World Vipers","author":"Mallow D","year":"2003"},{"key":"e_1_2_13_141_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1971.352.2.1183"},{"key":"e_1_2_13_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(78)90058-2"},{"key":"e_1_2_13_143_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1987.368.1.343"},{"key":"e_1_2_13_144_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050440"},{"key":"e_1_2_13_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(88)90342-7"},{"key":"e_1_2_13_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74123-5"},{"key":"e_1_2_13_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.106"},{"key":"e_1_2_13_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.01.174"},{"key":"e_1_2_13_149_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb17330.x"},{"key":"e_1_2_13_150_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444903014987"},{"key":"e_1_2_13_151_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00006450"},{"key":"e_1_2_13_152_2","first-page":"241","article-title":"Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action","volume":"144","author":"Chang CC","year":"1963","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_13_153_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1979.tb13278.x"},{"key":"e_1_2_13_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)01173-C"},{"key":"e_1_2_13_155_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0050-2"},{"key":"e_1_2_13_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00246-5"},{"key":"e_1_2_13_157_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6369538"},{"key":"e_1_2_13_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(72)90210-0"},{"key":"e_1_2_13_159_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh071"},{"key":"e_1_2_13_160_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508502200"},{"key":"e_1_2_13_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.016"},{"key":"e_1_2_13_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(92)90230-8"},{"key":"e_1_2_13_163_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648201"},{"key":"e_1_2_13_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00140-X"},{"key":"e_1_2_13_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80559-Y"},{"key":"e_1_2_13_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61479-6"},{"key":"e_1_2_13_167_2","first-page":"451","volume-title":"Handbook of Experimental Pharmacology","author":"Stocker K","year":"1977"},{"key":"e_1_2_13_168_2","first-page":"266","article-title":"Protein C activators from snake venoms and their diagnostic use","volume":"31","author":"Gempeler\u2010Messina PM","year":"2001","journal-title":"Haemostasis"},{"key":"e_1_2_13_169_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.17.10246"},{"key":"e_1_2_13_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.183"},{"key":"e_1_2_13_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.08.023"},{"key":"e_1_2_13_172_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.33.20531"},{"key":"e_1_2_13_173_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00160a036"},{"key":"e_1_2_13_174_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00127a005"},{"key":"e_1_2_13_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(67)80055-X"},{"key":"e_1_2_13_176_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560040301"},{"key":"e_1_2_13_177_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar50123a006"},{"key":"e_1_2_13_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)45249-0"},{"key":"e_1_2_13_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00119-1"},{"key":"e_1_2_13_180_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412900200"},{"key":"e_1_2_13_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(78)90246-2"},{"key":"e_1_2_13_182_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi951928k"},{"key":"e_1_2_13_183_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.621"},{"key":"e_1_2_13_184_2","first-page":"825","article-title":"Purification and characterization of a prothrombin activator from the venom of the Australian brown snake, Pseudonaja textilis textilis","volume":"17","author":"Masci PP","year":"1988","journal-title":"Biochem Int"},{"key":"e_1_2_13_185_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613264"},{"key":"e_1_2_13_186_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3839"},{"key":"e_1_2_13_187_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-03-0144"},{"key":"e_1_2_13_188_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-11-0707"},{"key":"e_1_2_13_189_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-07-0435"},{"key":"e_1_2_13_190_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01969.x"},{"key":"e_1_2_13_191_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02266.x"},{"key":"e_1_2_13_192_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06466.x"},{"key":"e_1_2_13_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.012"},{"key":"e_1_2_13_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.001"},{"key":"e_1_2_13_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2459"},{"key":"e_1_2_13_196_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1548"},{"key":"e_1_2_13_197_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00434.x"},{"key":"e_1_2_13_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/385733a0"},{"key":"e_1_2_13_199_2","doi-asserted-by":"publisher","DOI":"10.1038\/385729a0"},{"key":"e_1_2_13_200_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040424"},{"key":"e_1_2_13_201_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.052340"},{"key":"e_1_2_13_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.07.047"},{"key":"e_1_2_13_203_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.073287008"},{"key":"e_1_2_13_204_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909755106"},{"key":"e_1_2_13_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.07.009"},{"key":"e_1_2_13_206_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06099.x"},{"key":"e_1_2_13_207_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1392"},{"key":"e_1_2_13_208_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2530036.x"},{"key":"e_1_2_13_209_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3770"},{"key":"e_1_2_13_210_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601131"},{"key":"e_1_2_13_211_2","first-page":"699","volume-title":"Handbook of Metalloproteins","author":"Takeda S","year":"2010"},{"key":"e_1_2_13_212_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi9002315"},{"key":"e_1_2_13_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.029"},{"key":"e_1_2_13_214_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.04.057"},{"key":"e_1_2_13_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.062"},{"key":"e_1_2_13_216_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.014258"},{"key":"e_1_2_13_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00991-4"},{"key":"e_1_2_13_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.024"},{"key":"e_1_2_13_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.014"},{"key":"e_1_2_13_220_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn845"},{"key":"e_1_2_13_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49685-3"},{"key":"e_1_2_13_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34108-X"},{"key":"e_1_2_13_223_2","first-page":"179","volume-title":"Enzymes from Snake Venom","author":"Morita T","year":"1998"},{"key":"e_1_2_13_224_2","first-page":"225","article-title":"Snake venom activators of factor X: an overview","volume":"31","author":"Tans G","year":"2001","journal-title":"Haemostasis"},{"key":"e_1_2_13_225_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi981177x"},{"key":"e_1_2_13_226_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131179698"},{"key":"e_1_2_13_227_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9295-3_27"},{"key":"e_1_2_13_228_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1706"},{"key":"e_1_2_13_229_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0133"},{"key":"e_1_2_13_230_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.09.009"},{"key":"e_1_2_13_231_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005001000007"},{"key":"e_1_2_13_232_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1517"},{"key":"e_1_2_13_233_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050483"},{"key":"e_1_2_13_234_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05895.x"},{"key":"e_1_2_13_235_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604855200"},{"key":"e_1_2_13_236_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.10.034"},{"key":"e_1_2_13_237_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00799-3"},{"key":"e_1_2_13_238_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2009.11.009"},{"key":"e_1_2_13_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.021"},{"key":"e_1_2_13_240_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti770"},{"key":"e_1_2_13_241_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181505"},{"key":"e_1_2_13_242_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn790"},{"key":"e_1_2_13_243_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601175"},{"key":"e_1_2_13_244_2","volume-title":"An Introduction to Medicinal Chemistry. Cholinergics, Anticholinergics, and Anticholinesterase","author":"Patrick GL","year":"2001"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-4658.2011.08115.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2011.08115.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:39:03Z","timestamp":1741109943000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-4658.2011.08115.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,17]]},"references-count":243,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1742-4658.2011.08115.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08115.x","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,17]]}}}