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Despite this broad array of substrates, the physiological substrate of many ABC transporters has remained elusive. ABC transporters are divided into seven subfamilies, A\u2013G, based on sequence similarity and domain organization. Here we review the role of members of the ABCG subfamily in human disease and how the identification of disease genes helped to determine physiological substrates for specific ABC transporters. We focus on the recent discovery of mutations in\n                    <jats:italic>ABCG2<\/jats:italic>\n                    causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2.\n                  <\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08171.x","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T11:24:23Z","timestamp":1304767463000},"page":"3215-3225","source":"Crossref","is-referenced-by-count":68,"title":["ABCG transporters and disease"],"prefix":"10.1111","volume":"278","author":[{"given":"Owen 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