{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:13:49Z","timestamp":1791184429895,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Functional protein serotonylation is a newly recognized post\u2010translational modification with the primary biogenic monoamine (PBMA) serotonin (5\u2010HT). This covalent protein modification is catalyzed by transglutaminases (TGs) and, for example, acts in the constitutive activation of small GTPases. Multiple physiological roles have been identified since its description in 2003 and, importantly, deregulated serotonylation was shown in the etiology of bleeding disorders, primary pulmonary hypertension and diabetes. The PBMAs 5\u2010HT, histamine, dopamine, and norepinephrine all act as neurotransmitters in the nervous system and as hormones in non\u2010neuronal tissues, which points out their physiological importance. In analogy to serotonylation we have found that also the other PBMAs act through the TG\u2010catalyzed mechanisms of \u2018histaminylation\u2019, \u2018dopaminylation\u2019 and \u2018norepinephrinylation\u2019. Therefore, PBMAs deploy a considerable portion of their effects via protein monoaminylation in addition to their canonical receptor\u2010mediated signaling. Here, the implications of these newly identified post\u2010translational modifications are presented and discussed. Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G\u2010protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed.<\/jats:p>","DOI":"10.1111\/j.1742-4658.2011.08347.x","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T23:16:16Z","timestamp":1316214976000},"page":"4740-4755","source":"Crossref","is-referenced-by-count":77,"title":["Novel roles for biogenic monoamines: from monoamines in transglutaminase\u2010mediated post\u2010translational protein modification to monoaminylation deregulation diseases"],"prefix":"10.1111","volume":"278","author":[{"given":"Diego J.","family":"Walther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Stahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Vowinckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147990"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00556-2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.108.2804.329"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01014-6"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi035656u"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100408"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00046-7"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000252210.58849.78"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805-691OC"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604195200"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078197"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08345.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000229"},{"key":"e_1_2_9_15_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.55782\/ane-1996-1167","article-title":"Evolutionary ancient roles of serotonin: long\u2010lasting regulation of activity and development","volume":"56","author":"Turlejski K","year":"1996","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-005-6876-6"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088451"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00187-2"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20256"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10990"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1556\/ABiol.55.2004.1-4.36"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/43.12.8537641"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/43.2.7822777"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00614-1"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5530"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71020460.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20293"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800635"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-004-0152-y"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502107200"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2003.185.pe22"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.11.7224-7228.2005"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3930.438"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.01.015"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212816200"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123842"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00022-X"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008956"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001557"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/374640a0"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/374643a0"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90145-0"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10540-005-2896-3"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00746-8"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.032"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80655-8"},{"key":"e_1_2_9_47_2","first-page":"238","article-title":"5\u2010Hydroxytryptamine receptors. An example for the complexity of chemical transmission of information in the brain","volume":"42","author":"Gothert M","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1212OC"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6_suppl.552S"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050044"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2000.0307"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00263.x"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb01918.x"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040606"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014960026247"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1997.tb00337.x"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91697-5"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/35.3.3819375"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603204200"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00015-8"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.2741\/1863"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.2741\/1789"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.03.063"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084232"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2004.04476.x"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-004-0091-7"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1014"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(02)02182-5"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021234"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.2741\/1921"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00357005"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2004.03.009"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90413-8"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(68)90557-2"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/1911204a0"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1976.tb02630.x"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb07779.x"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.05.003"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38792-6"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-27511-8_10"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10254-004-0026-4"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/42743"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/42735"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01132-7"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600863200"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/89610"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2000.054"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.28999"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005682"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706367200"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1124\/mi.10.4.6"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.135046"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1984-7"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1657"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2010.00131"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01119629"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.15.10311"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0775"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.08.044"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7091.2007"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1163"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1984-7"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0078OC"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.04.020"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-4658.2011.08347.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2011.08347.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T21:00:26Z","timestamp":1712869226000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-4658.2011.08347.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":103,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1742-4658.2011.08347.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08347.x","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}