{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:06:15Z","timestamp":1787504775364,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Heat shock proteins (HSPs) are a highly conserved family of proteins that are induced in response to various environmental stressors including reactive oxygen species. HSP27 is a chaperone protein with the ability to increase cell survival in response to oxidative stress. Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Although the mechanism of PD remains unclear, oxidative stress is known to be important in its pathogenesis. This study investigated the protective effects of PEP\u20101\u2010HSP27 on neuronal damage induced by 1\u2010methyl\u20104\u2010phenyl pyridinium (MPP\n                    <jats:sup>+<\/jats:sup>\n                    ) in SH\u2010SY5Y cells and in a 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010induced PD mouse model. PEP\u20101\u2010HSP27 rapidly entered the cells and protected them against MPP\n                    <jats:sup>+<\/jats:sup>\n                    \u2010induced toxicity by inhibiting the reactive oxygen species levels and DNA fragmentation. Furthermore, transduced PEP\u20101\u2010HSP27 prevented dopaminergic neuronal cell death in the substantia nigra of MPTP\u2010induced PD mouse models. These results demonstrate that PEP\u20101\u2010HSP27 provides a potential strategy for therapeutic delivery against various diseases and is a potential tool for the treatment of PD.\n                  <\/jats:p>","DOI":"10.1111\/j.1742-4658.2012.08574.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T09:52:32Z","timestamp":1332150752000},"page":"1929-1942","source":"Crossref","is-referenced-by-count":16,"title":["PEP\u20101\u2010heat shock protein 27 protects from neuronal damage in cells and in a Parkinson\u2019s disease mouse model"],"prefix":"10.1111","volume":"279","author":[{"given":"Yeom Pyo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye 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