{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:49:08Z","timestamp":1767340148797},"reference-count":29,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>In an accompanying paper [du Preez <jats:italic>et\u00a0al.<\/jats:italic>, (2012) <jats:italic>FEBS J<\/jats:italic><jats:bold>279<\/jats:bold>, 2810\u20132822], we adapt an existing kinetic model for steady\u2010state yeast glycolysis to simulate limit\u2010cycle oscillations. Here we validate the model by testing its capacity to simulate a wide range of experiments on dynamics of yeast glycolysis. In addition to its description of the oscillations of glycolytic intermediates in intact cells and the rapid synchronization observed when mixing out\u2010of\u2010phase oscillatory cell populations (see accompanying paper), the model was able to predict the Hopf bifurcation diagram with glucose as the bifurcation parameter (and one of the bifurcation points with cyanide as the bifurcation parameter), the glucose\u2010 and acetaldehyde\u2010driven forced oscillations, glucose and acetaldehyde quenching, and cell\u2010free extract oscillations (including complex oscillations and mixed\u2010mode oscillations). Thus, the model was compliant, at least qualitatively, with the majority of available experimental data for glycolytic oscillations in yeast. To our knowledge, this is the first time that a model for yeast glycolysis has been tested against such a wide variety of independent data sets.<\/jats:p><jats:p><jats:bold>Database<\/jats:bold>\n          \u2028The mathematical models described here have been submitted to the JWS Online Cellular Systems Modelling Database and can be accessed at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/jjj.biochem.sun.ac.za\/database\/dupreez\/index.html\">http:\/\/jjj.biochem.sun.ac.za\/database\/dupreez\/index.html<\/jats:ext-link>.<\/jats:p>","DOI":"10.1111\/j.1742-4658.2012.08658.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T19:03:12Z","timestamp":1339441392000},"page":"2823-2836","source":"Crossref","is-referenced-by-count":23,"title":["From steady\u2010state to synchronized yeast glycolytic oscillations II: model validation"],"prefix":"10.1111","volume":"279","author":[{"given":"Franco B.","family":"du 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