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Wound bed preparation is a modern approach for the removal of local barriers to healing by optimising debridement, reduction of bioburden and exudate management through the TIME principles, which have been introduced by the International Advisory Board on Wound Bed Preparation. However, this protocol does not evaluate the state of the repair process and therefore does not suggest the ideal therapeutic choice for each single patient. The revised TIME\u2010H concept considers also the supposed healing time, H, and gives a score that correlates the wound condition with the incidental concomitance with medical pathologies related to the therapeutic measures, thus guiding the clinician towards a practical and systematic approach in the treatment. By applying this scheme to our situation, the average healing time was considerably reduced. The formulation of the new protocol TIME\u2010H for a critical assessment of treatment scheme, which also includes the general conditions of the patient, represents a more rational and adequate approach for an accurate prognosis and therefore for a more suitable therapeutic choice in the treatment of difficult wounds.<\/jats:p>","DOI":"10.1111\/j.1742-481x.2006.00280.x","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T18:22:06Z","timestamp":1175797326000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Wound bed preparation of difficult wounds: an evolution of the principles of TIME"],"prefix":"10.1111","volume":"4","author":[{"given":"Claudio","family":"Ligresti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2000.00347.x"},{"issue":"9","key":"e_1_2_5_3_2","first-page":"405","article-title":"Developments in wound care for difficult to manage wounds","volume":"200","author":"Ballard K","journal-title":"Br J Nurs"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.1304S1.x"},{"key":"e_1_2_5_5_2","first-page":"14","article-title":"Preparing the wound bed\u2014debridement, bacterial balance, and moisture balance","volume":"46","author":"Sibbald G","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_5_6_2","first-page":"57","article-title":"Wound assessment and documentation","volume":"8","author":"Van Rijswijk L","year":"1996","journal-title":"Wounds"},{"key":"e_1_2_5_7_2","first-page":"30","article-title":"The scientific basis of healing","volume":"10","author":"Kerstein MD","year":"1997","journal-title":"Adv Wound Care"},{"key":"e_1_2_5_8_2","first-page":"66","article-title":"Quantifying wound fluids for the clinician and researcher","volume":"40","author":"Mulder GD","year":"1994","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_5_9_2","first-page":"24","article-title":"Pressure ulcer prevalence, cost and risk assessment: consensus development conference statement","volume":"2","author":"NPUAP (National Pressure Ulcer Advisory Board)","year":"1989","journal-title":"Decubitus"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb06239.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2307\/3471209"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(98)00034-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10603.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131306"},{"key":"e_1_2_5_15_2","volume-title":"An investigation of geriatric nursing problems in hospitals","author":"Norton D","year":"1962"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-197301000-00008"},{"key":"e_1_2_5_17_2","first-page":"32","article-title":"Pressure sore risk assessment: a critique. 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