{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:34:31Z","timestamp":1785717271181,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T00:00:00Z","timestamp":1340755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Massive skin defects caused by severe burn and trauma are a clinical challenge to surgeons. Timely and effective wound closure is often hindered by the lack of skin donor site. Bone marrow\u2010derived cells (BMDCs) have been shown to \u2018differentiate\u2019 into multiple tissue cells. In this study we focused on the direct manipulation of endogenous BMDCs, avoiding the immunocompatibility issues and complicated cell isolation, purification, identification and amplification procedures in vitro on wound repair. We found that mobilisation of the BMDCs into the circulation significantly increased the amount of BMDCs at the injury site which in turn accelerated healing of large open wound. We used a chimeric green fluorescent protein (GFP) mouse model to track BMDCs and to investigate their role in full\u2010thickness skin excisional wounds. We have shown that bone marrow mobilisation by granulocyte colony stimulating factor (G\u2010CSF) exerted multiple beneficial effects on skin repair, both by increasing the engraftment of BMDCs into the skin to differentiate into multiple skin cell types and by upregulating essential cytokine mRNAs critical to wound repair. The potential trophic effects of G\u2010CSF on bone marrow stem cells to accelerate wound healing could have a significant clinical impact.<\/jats:p>","DOI":"10.1111\/j.1742-481x.2012.01007.x","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T07:29:44Z","timestamp":1340782184000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mobilised bone marrow\u2010derived cells accelerate wound healing"],"prefix":"10.1111","volume":"10","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Zhao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Fan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.02.002"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00942.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0B013E318093E44C"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00410.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.12.011"},{"key":"e_1_2_7_9_2","first-page":"40","article-title":"Adult stem cells applied to tissue engineering and regenerative medicine","volume":"54","author":"Cuenca\u2010Lopez MD","year":"2008","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0428"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.040"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22236"},{"key":"e_1_2_7_13_2","article-title":"Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a phase I clinical trial","author":"Mazzini L","year":"2009","journal-title":"Exp Neurol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/86498"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2005.00329.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920107780906478"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1465-3249(05)70784-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000057814.70180.17"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3496fje"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000178809.01289.10"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4763fje"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.04.023"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00584.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00696.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01260-4"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2009.0750"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(08)80114-X"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-481X.2012.01007.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-481X.2012.01007.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-481X.2012.01007.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:33:42Z","timestamp":1694817222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-481X.2012.01007.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,27]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1742-481X.2012.01007.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-481x.2012.01007.x","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,27]]},"assertion":[{"value":"2012-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}