{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:57:46Z","timestamp":1696309066801},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Due to similarities in skin characteristics, the authors hypothesise that a pig model would most accurately show the ability of autologous, enhanced cryoprecipitate (eCryo) to improve the wound healing of split\u2010thickness skin grafts (STSGs) and corresponding donor sites. Fifty\u2010two STSGs (5 \u00d7 5 cm) were fashioned and treated according to a randomised protocol with an autologous eCryo\u2010treated and a control group. Macroscopic assessment, histological evaluation and cellular composition were completed at days 7, 14, 21 and 28. Thirty\u2010two donor sites were also created and assessed in a similar manner. Histologic analysis showed enhancement of healing over all time points for eCryo\u2010treated donor sites. All other results showed no statistically significant improvement with the use of eCryo. Autologous cryoprecipitate appears to be a safe, inexpensive and easy\u2010to\u2010use alternative to fibrin glue, which carries risks and is, in many cases, prohibitively expensive. Further studies are necessary to evaluate the full potential of eCryo. Interestingly, eCryo application may improve donor site aesthetic appearance. We believe that a pig model most reliably simulates eCryo's behaviour in humans to accurately reflect its future clinical applicability.<\/jats:p>","DOI":"10.1111\/j.1742-481x.2012.01059.x","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T09:13:15Z","timestamp":1345540395000},"page":"169-176","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced cryoprecipitate for skin graft and donor site wound healing in pigs"],"prefix":"10.1111","volume":"11","author":[{"given":"Thomas Sebastian","family":"Vetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S","family":"Mowlds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su 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