{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:36:36Z","timestamp":1788572196206,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scrub typhus is an infectious disease that is caused by <jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rientia tsutsugamushi<\/jats:italic>. The authors describe an autopsied case of scrub typhus complicated with severe disseminated intravascular coagulation (<jats:styled-content style=\"fixed-case\">DIC)<\/jats:styled-content>. An 82\u2010year\u2010old man complained of fever 4\u2009days after climbing a mountain. The patient was admitted to an urban hospital, and meropenem and ceftriaxone were administered. The patient's condition deteriorated and he was transferred to a second hospital. On physical examination, a black scab was found and scrub typhus was suspected. Despite intensive treatment, the patient died on the fifth day. High levels of <jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>.\u2009tsutsugamushi<\/jats:italic> <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> antibody were confirmed. An autopsy revealed systemic vasculitis and perivasculitis. The endothelial tissue of the white pulp of the spleen was markedly infiltrated by plasma cells. The authors speculated that a severe immune reaction against <jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>.\u2009tsutsugamushi<\/jats:italic> enhanced an inflammatory response, leading to <jats:styled-content style=\"fixed-case\">DIC<\/jats:styled-content>. This case is a warning to doctors who are not familiar with scrub typhus.<\/jats:p>","DOI":"10.1111\/j.1742-6723.2012.01600.x","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T07:38:08Z","timestamp":1349681888000},"page":"577-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Case of scrub typhus complicated by severe disseminated intravascular coagulation and death"],"prefix":"10.1111","volume":"24","author":[{"given":"Yuko","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahumi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pathology Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choichiro","family":"Tase","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"385","article-title":"A severe case of Tsutsugamushi disease with disseminated intravascular coagulation and acute respiratory distress syndrome","volume":"46","author":"Izumo T","year":"2008","journal-title":"J. Jpn Respir. Soc."},{"key":"e_1_2_6_3_1","first-page":"575","article-title":"A case of Tsutsugamushi disease with pneumonia and DIC","volume":"65","author":"Sugimura S","year":"2006","journal-title":"Jpn J. Chest Dis."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01492043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01833873"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540500277342"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.17.S48"},{"key":"e_1_2_6_8_1","first-page":"603","article-title":"A comparative study of the pathology of scrub typhus (tsutsugamushi disease) and other rickettsial diseases","volume":"21","author":"Allen AC","year":"1945","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880385"},{"key":"e_1_2_6_10_1","first-page":"2221","article-title":"A case of tsutsugamushi disease associated with disseminated intravascular coagulation, acute renal failure and interstitial pneumonia and a review of 20 cases of tsutsugamushi disease in Nagaoka Red Cross Hospital","volume":"109","author":"Mutsushita A","year":"1999","journal-title":"Jpn J. Dermatol."}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-6723.2012.01600.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-6723.2012.01600.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:43:42Z","timestamp":1695480222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-6723.2012.01600.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1742-6723.2012.01600.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-6723.2012.01600.x","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"2012-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}