{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:25:49Z","timestamp":1787505949467,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2012,10]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n I<\/jats:styled-content>\n rukandji syndrome is a distressing condition characterised by pain, hypertension and tachycardia. Some develop cardiac failure and there have been two reported deaths. Magnesium sulphate has become the standard of care despite minimal evidence. The aim of this study was to investigate if magnesium would reduce analgesic requirement and length of stay for patients with\n I<\/jats:styled-content>\n rukandji syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a double\u2010blind, randomised controlled clinical trial. Patients with\n I<\/jats:styled-content>\n rukandji syndrome who required parenteral opioid analgesia were randomised to receive either 10\u2009mmol of magnesium as a bolus, and then a 5\u2009mmol\/h magnesium infusion for 6\u2009h or saline. Fentanyl patient\u2010controlled analgesia was commenced to allow patients to self\u2010regulate their pain relief. The primary outcome measure of the study was comparison of total analgesic requirements between the two groups. The secondary outcome measure was to compare length of stay.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study ran from\n N<\/jats:styled-content>\n ovember 2003 to\n M<\/jats:styled-content>\n ay 2007. Thirty\u2010nine patients were enrolled in the study; 26 were male with a median age of 28. Twenty\u2010two received magnesium. There was no significant difference in the morphine equivalent dose used, peak\n CK<\/jats:styled-content>\n , peak troponin, peak pulse, peak blood pressure, peak mean arterial pressure (\n MAP<\/jats:styled-content>\n ), percentage\n MAP<\/jats:styled-content>\n rise and length of stay for those receiving magnesium compared with placebo.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our study did not demonstrate a benefit in the use of magnesium in the treatment of\n I<\/jats:styled-content>\n rukandji syndrome. As such the current use of magnesium needs to be reconsidered until there is good evidence to support its use.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1742-6723.2012.01602.x","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T23:18:44Z","timestamp":1347405524000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Randomised trial of magnesium in the treatment of\n I<\/scp>\n rukandji syndrome"],"prefix":"10.1111","volume":"24","author":[{"given":"Nora","family":"McCullagh","sequence":"first","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pereira","sequence":"additional","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"},{"name":"Department of Tropical Biology James Cook University Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cullen","sequence":"additional","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mulcahy","sequence":"additional","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bonin","sequence":"additional","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Little","sequence":"additional","affiliation":[{"name":"Emergency Department Cairns Base Hospital Cairns Queensland Australia"},{"name":"School of Public Health and Tropical Medicine James Cook University Cairns Queensland Australia"},{"name":"Queensland Tropical Health Alliance Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Gray","sequence":"additional","affiliation":[{"name":"Peel Health Campus Mandurah Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Seymour","sequence":"additional","affiliation":[{"name":"School of Public Health and Tropical Medicine James Cook University Cairns Queensland Australia"},{"name":"Queensland Tropical Health Alliance Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2003.tb05040.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.09.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2003.tb05263.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0403200510"},{"key":"e_1_2_6_6_1","unstructured":"Queensland Ambulance Service.Magnesium Sulphate in Drug Therapy Protocol 1.019. Updated 21 September2009. Available from URL:http:\/\/www.ambulance.qld.gov.au\/medical\/pdf\/Magnesium_sulfate_DTP_1.019_Ver_1.2.0.pdf[Accessed 31 August 2012]."},{"key":"e_1_2_6_7_1","unstructured":"PereiraP CorkeronM LittleMet\u2009al.Irukandji Taskforce guidelines for the emergency management of Irukandji syndrome. Available from URL:http:\/\/www.marinestingers.com.au\/pdf\/msar_0910.pdf[Accessed 31 August 2012]."},{"key":"e_1_2_6_8_1","first-page":"541","article-title":"Failure of magnesium in treatment of Irukandji syndrome","volume":"33","author":"Little M","year":"2005","journal-title":"Anaesth. Intensive Care"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.873"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1742-6723.2012.01602.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-6723.2012.01602.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T10:43:23Z","timestamp":1695465803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-6723.2012.01602.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1742-6723.2012.01602.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1742-6723.2012.01602.x","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]},"assertion":[{"value":"2012-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}