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The KRGE significantly prevented rat carotid arterial thrombosis <jats:italic>in vivo<\/jats:italic> in a dose\u2010dependent manner. Administration of the KRGE to rats significantly inhibited adenosine diphosphate (ADP)\u2010 and collagen\u2010induced platelet aggregation <jats:italic>ex vivo<\/jats:italic>, although it failed to prolong coagulation times such as activated partial thromboplastin and prothrombin time indicating that the antithrombotic effect of the red ginseng may be due to its antiplatelet aggregation rather than anticoagulation effect. In line with the above observations, the red ginseng inhibited the U46619\u2010, arachidonic acid\u2010, collagen\u2010 and thrombin\u2010induced rabbit platelet aggregations <jats:italic>in vitro<\/jats:italic> in a concentration\u2010dependent manner, with IC<jats:sub>50<\/jats:sub> values of 390\u00a0\u00b1\u00a015, 485\u00a0\u00b1\u00a019, 387\u00a0\u00b1\u00a011 and 335\u00a0\u00b1\u00a015\u00a0\u00b5g\/ml, respectively. Consistently, serotonin secretion was also inhibited by ginseng in the same pattern. These results suggest that the red ginseng has a potent antithrombotic effect <jats:italic>in vivo<\/jats:italic>, which may be due to the antiplatelet rather than the anticoagulation activity, and the red ginseng intake may be beneficial for individuals with high risks of thrombotic and cardiovascular diseases.<\/jats:p>","DOI":"10.1111\/j.1742-7843.2006.00033.x","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T21:25:14Z","timestamp":1168982714000},"page":"170-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Antithrombotic and Antiplatelet Activities of Korean Red Ginseng Extract"],"prefix":"10.1111","volume":"100","author":[{"given":"Yong\u2010Ri","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon\u2010Hyang","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yoon","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hyun","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tack\u2010Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong\u2010Soeb","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Joon","family":"Wee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo\u2010Pyo","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80010-9"},{"key":"e_1_2_6_3_2","first-page":"I16","article-title":"Unstable angina pectoris. 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