{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T14:10:15Z","timestamp":1713103815595},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:00:00Z","timestamp":1323129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>A number of drugs, like sibutramine, which are used clinically in weight control, act on serotonergic metabolism. However, their relation with zinc and free radical (FR) production in central nervous system remains unknown. This study aimed to evaluate the effect of sibutramine and zinc on FR production. Female Wistar rats (about 250\u2003g) were used in this study. The animals received 400\u2003\u03bcg\/kg of zinc and 10\u2003mg\/kg of sibutramine intraperitoneally every 36\u2003hr for 15\u2003days. At the end of the study, the rats were killed and their brains used for the measurement of lipid peroxidation thiobarbituric acid\u2010reactive substances (TBARS), reduced glutathione (GSH), hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), calcium and 5\u2010hydroxyindole acetic acid (5\u2010HIAA) levels, all by means of validated methods. Corporal weight and food consumption were found to be decreased in the zinc\/sibutramine group. TBARS decreased in cortex, hemispheres and medulla oblongata. GSH decreased in cortex, hemispheres and cerebellum in the sibutramine group. Zinc given alone and in combination with sibutramine decreased H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>concentration in cortex, hemispheres and cerebellum but increased calcium and 5\u2010HIAA concentration in all brain regions. Our results suggest that sibutramine and zinc are associated with weight loss, an effect that was more pronounced in the group treated with both drugs. Reduction in oxidative stress may be involved in these effects.<\/jats:p>","DOI":"10.1111\/j.1742-7843.2011.00829.x","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T12:34:43Z","timestamp":1320669283000},"page":"421-426","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Sibutramine on 5\u2010Hydroxyindole Acetic Acid Levels and Selected Oxidative Biomarkers on Brain Regions of Female Rats in the Presence of Zinc"],"prefix":"10.1111","volume":"110","author":[{"given":"David C.","family":"Guzm\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernestina H.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo B.","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo J.","family":"Olgu\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca T.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick B.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"del Angel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana C.","family":"Aparicio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,6]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"National Survey about Health and Nutrition 2006. 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