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This project has determined whether induction of morphine dependence in rats by gradually increasing morphine doses for 21\u00a0days induces structural and functional changes in the cardiovascular system because of mineralocorticoid receptor activation, as morphine increases plasma corticosterone concentrations. Morphine\u2010dependent rats showed ventricular hypertrophy, increased collagen deposition in the left ventricle together with an increased ventricular stiffness and increased plasma malondialdehyde concentrations without changes in systolic blood pressure or thoracic aortic responsiveness. These parameters were attenuated or normalised in morphine\u2010dependent rats treated with spironolactone (50\u00a0mg\/kg\/day) from days 14\u201321. These results suggest that morphine dependence induces ventricular remodelling and increased oxidative stress that can be prevented by the mineralocorticoid receptor antagonist, spironolactone.<\/jats:p>","DOI":"10.1111\/j.1742-7843.2012.00860.x","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T18:06:23Z","timestamp":1328292383000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mineralocorticoid Receptors Mediate Cardiac Remodelling in Morphine\u2010Dependent Rats"],"prefix":"10.1111","volume":"111","author":[{"given":"Azadeh","family":"Mesripour","sequence":"first","affiliation":[{"name":"Medical Plants Research Centre Shahrekord University of Medical Sciences Shahrekord, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abishek","family":"Iyer","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00003.2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000172130.70274.84"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000299437.93898.4a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04986.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.09.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.03.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00984-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000115148.03515.56"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200007000-00010"},{"key":"e_1_2_6_11_1","first-page":"S148","article-title":"Reversal of cardiac fibrosis in deoxycorticosterone acetate\u2010salt hypertensive rats by inhibition of the renin\u2010angiotensin system","volume":"10","author":"Brown L","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_12_1","first-page":"863","article-title":"Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists","volume":"233","author":"Eisenberg RM","year":"1985","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890802659612"},{"key":"e_1_2_6_14_1","first-page":"77","article-title":"The effects of spironolactone on recognition memory loss induced by morphine withdrawal in mice","volume":"2","author":"Mesripour A","year":"2007","journal-title":"Res Pharm Sci"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1982.tb09165.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00956-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00140.2005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(83)90365-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91879-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.002453"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.588"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706456"},{"key":"e_1_2_6_23_1","first-page":"41","article-title":"Identification and role of aldosterone receptors in the cardiovascular system","volume":"61","author":"Lombes M","year":"2000","journal-title":"Ann Endocrinol (Paris)"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039104.56479.42"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.111258"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01243-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01729-6"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20324"}],"container-title":["Basic &amp; 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