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It is well established that endogenous nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) contributes to chronic unpredictable mild stress (<jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content>)\u2010induced depression. The aim of this study was to investigate brain\u2010derived neurotropic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) expression in <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content>\u2010induced depression\u2010like behaviour in rats. Rats were exposed to <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content> for 5\u00a0weeks. A specific and selective n<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> inhibitor, 3\u2010bromo\u20107\u2010nitroindazole (3\u2010Br\u20107\u2010NI; 20\u00a0mg\/kg\/day, i.p.), and a specific soluble guanylate cyclase (s<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) inhibitor, 1H\u2010(1,2,4)oxadiazolo(4,3\u2010a)quinoxalin\u20101\u2010one (<jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content>; 10\u00a0mg\/kg\/day, i.p.), were administered during <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content>. The forced swimming test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>) was used to assess despair and sucrose consumption, and sucrose preference test was used to assess anhedonia that are the main symptoms of the depression. We show that both 3\u2010Br\u20107\u2010NI and <jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content> administration during <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content> suppressed <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content>\u2010induced, depression\u2010like behavioural changes, including reduced sucrose preference, body\u2010weight and locomotor activity as well as increased immobility time in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content> also significantly decreased <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> protein levels in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 regions of the hippocampus, which was reversed by 3\u2010Br\u20107\u2010NI and <jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content> administration. Our findings suggest a novel role for n<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> and s<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010c<jats:styled-content style=\"fixed-case\">GMP<\/jats:styled-content> in the development of the <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content> model of depression.<\/jats:p>","DOI":"10.1111\/j.1742-7843.2012.00877.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T19:49:20Z","timestamp":1330976960000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Inhibition of Neuronal Nitric Oxide Synthase and Soluble Guanylate Cyclase Prevents Depression\u2010Like Behaviour in Rats Exposed to Chronic Unpredictable Mild Stress"],"prefix":"10.1111","volume":"111","author":[{"given":"Yusufhan","family":"Yazir","sequence":"first","affiliation":[{"name":"Department of 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