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Purified down to a low\u2010molecular\u2010weight fraction and characterized by high\u2010performance liquid chromatography\u2013mass spectrometry, the material, named SBD.4A, revealed a particularly strong wound healing activity in the diabetic mouse wound\u2010healing model, and in the human\/severe combined immunodeficiency mouse chimera wound\u2010healing model. In both models, SBD.4A compared favorably with the Food and Drug Administration\u2010approved wound\u2010healing drug becaplermin, suggesting that this botanical product could be a valuable treatment for difficult\u2010to\u2010heal wounds. Further high\u2010performance liquid chromatography fractionation of SBD.4A yielded a hydrophilic fraction, which strongly stimulated endothelial cell proliferation, tridimensional endothelial cell network formation, as well as the proliferation of human dermal fibroblasts and type I collagen secretion. Because angiogenesis and fibroblast proliferation are essential for wound healing, we propose that this liquid chromatography\u2013mass spectrometry\u2010defined hydrophilic fraction is at least partially responsible for the wound\u2010healing activity of SBD.4A.<\/jats:p>","DOI":"10.1111\/j.1743-6109.2006.00166.x","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T15:44:03Z","timestamp":1159544643000},"page":"593-601","source":"Crossref","is-referenced-by-count":13,"title":["SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin\/severe\u2010combined immunodeficiency mouse 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