{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:06:14Z","timestamp":1777068374759,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Erectile dysfunction (ED) is a common condition with diverse sequelae affecting men and their women partners.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The FINDER study aimed to evaluate the efficacy and tolerability of the phosphodiesterase type-5 (PDE5) inhibitor, vardenafil, in a broad population of PDE5-na\u00efve men with ED of different etiologies and severity and included their partners\u2019 assessments of treatment with vardenafil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Men with ED (N = 260) were randomized to receive either vardenafil or placebo in a multicenter, flexible-dose study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Primary efficacy variables were patients\u2019 responses to the Global Assessment Question (GAQ), and Sexual Encounter Profile questions 2 and 3 (SEP2 and SEP3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with placebo, vardenafil significantly improved rates of successful \u201cYes\u201d responses to SEP3 (\u201cDid your erection last long enough for you to have successful intercourse?\u201d) (49% placebo vs. 78% vardenafil at last period carried forward [LPCF]; P &amp;lt; 0.0001), SEP2 (\u201cWere you able to insert your penis into your partner\u2019s vagina?\u201d) (65% placebo vs. 85% vardenafil at LPCF; P &amp;lt; 0.0001), and GAQ (36% placebo vs. 83% vardenafil at last observation carried forward; P &amp;lt; 0.0001). In addition, patients\u2019 and their partners\u2019 Treatment Satisfaction Scale (TSS) scores were statistically significantly improved across each of the TSS domains (satisfaction with orgasm, ease with erection, confidence, pleasure, erectile function satisfaction, and satisfaction with medication) in the vardenafil group compared with the placebo group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Vardenafil improved sexual function to the extent that both patients and their partners expressed a considerable and agreed level of satisfaction with treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/j.1743-6109.2006.00329.x","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T10:45:27Z","timestamp":1161859527000},"page":"1028-1036","source":"Crossref","is-referenced-by-count":49,"title":["Vardenafil Improves Sexual Function and Treatment Satisfaction in Couples Affected by Erectile Dysfunction (ED): A Randomized, Double-Blind, Placebo-Controlled Trial in PDE5 Inhibitor-Na\u00efve Men with ED and Their Partners"],"prefix":"10.1093","volume":"3","author":[{"given":"David","family":"Edwards","sequence":"first","affiliation":[{"name":"The White House Surgery , Chipping Norton"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Hackett","sequence":"additional","affiliation":[{"name":"Good Hope Hospital , Sutton Coldfield"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Collins","sequence":"additional","affiliation":[{"name":"Bayer, Inc. , Newbury , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Curram","sequence":"additional","affiliation":[{"name":"Bayer, Inc. , Newbury , 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