{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T05:54:36Z","timestamp":1673157276391},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Priapism is a common concern in sickle cell disease. With a high frequency of recurrences and serious long-term sequela, a preventative, rather than traditionally reactive approach, needs to be taken in these patients. Reports have shown successful use of sildenafil as a prophylactic treatment but have failed to address adverse outcomes, including vasoocclusive pain crises, of chronic sildenafil therapy in sickle cell patients.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n We wish to draw attention to the potential adverse outcomes of this therapy on the overall state of the patient's disease for consideration in future studies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We used sildenafil in a patient suffering from almost daily attacks of priapism.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sildenafil was successful in decreasing the frequency of priapism; however, our patient experienced an increased frequency of vasoocclusive crises, something not previously addressed.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Future studies of sildenafil use in sickle cell disease need to assess the global state of the disease, not just the frequency of priapism.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1743-6109.2011.02440.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T01:04:39Z","timestamp":1314839079000},"page":"3193-3195","source":"Crossref","is-referenced-by-count":2,"title":["Potential Risks of Chronic Sildenafil Use for Priapism in Sickle Cell Disease"],"prefix":"10.1093","volume":"8","author":[{"given":"Andrew","family":"Lane","sequence":"first","affiliation":[{"name":"Florida State University College of Medicine , Tallahassee, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby","family":"Deveras","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine , Tallahassee, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"2023010704072921200_bb0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrurol.2009.50","article-title":"Evaluation and management of priapism: 2009 update","volume":"6","author":"Huang","year":"2009","journal-title":"Nat Rev Urol"},{"key":"2023010704072921200_bb0015","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.hoc.2005.08.003","article-title":"Priapism in sickle cell disease","volume":"19","author":"Rogers","year":"2005","journal-title":"Hematol Oncol Clin North Am"},{"key":"2023010704072921200_bb0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2164\/jandrol.110.010934","article-title":"A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: Report of an international randomized control trial; 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