{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:53:18Z","timestamp":1764193998138},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T00:00:00Z","timestamp":1341792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To<\/jats:bold> analyze the clinical and biological characteristics of adult BAL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We identified 22 cases (4.4%) of BAL<\/jats:styled-content> from 496 newly diagnosed acute leukemia patients and compared them with patients with acute myloid leukemia (AML<\/jats:styled-content>) and acute lymphoblastic leukemia (ALL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>CD<\/jats:styled-content>34 positivity was higher in BAL<\/jats:styled-content> (87%) than in ALL<\/jats:styled-content> (60%, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.04) and AML<\/jats:styled-content> patients (63%, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.05). The median age in the BAL<\/jats:styled-content> group was greater than in ALL<\/jats:styled-content> (43 vs<\/jats:italic> 31 years, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.04). Enlargement of liver, spleen and lymphonodes was more common in BAL<\/jats:styled-content> (81.8%) than AML<\/jats:styled-content> (46%, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.003). Cytogenetic analysis revealed abnormal karyotypes in 56% of BAL<\/jats:styled-content> patients. The overall completed remission rate in the BAL<\/jats:styled-content> group (65%) was lower than in ALL<\/jats:styled-content> (86%, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>BAL<\/jats:styled-content> patients showed a much higher incidence of older age, CD<\/jats:styled-content>34 antigen expression, presence of Philadelphia chromosome, liver, spleen and lymphonodes infiltration and resistance to therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1743-7563.2012.01571.x","type":"journal-article","created":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T02:49:18Z","timestamp":1341888558000},"page":"146-154","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and laboratory features of adult biphenotypic acute leukemia"],"prefix":"10.1111","volume":"9","author":[{"given":"Haixia","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Blood 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