{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:44:26Z","timestamp":1789969466239,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T00:00:00Z","timestamp":1141257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as <jats:italic>fogo selvagem<\/jats:italic> (wild fire) in Brazil, the disease has distinct epidemiological characteristics, being endemic in certain regions of South America. It is a multifactorial (complex) disease, with oligo\u2010 or polygenic disease susceptibility. In view of the previously reported evidences of a role for apoptosis dysregulation in pemphigus pathogenesis, we hypothesized that genetic variants of molecules participating in apoptosis may contribute to interindividual variation of susceptibility to PF. The <jats:italic>TP53<\/jats:italic> 12139(G,C) and the <jats:italic>BAX<\/jats:italic>\u2212248(G,A) single nucleotide polymorphisms (SNP) were analysed in a genetic association study. The allelic, genotypic and allele carrier frequencies for these SNPs did not differ statistically between the patient and the control groups, for both the Euro\u2010 and the Afro\u2010Brazilian population strata. The results of this study lead us to conclude that, although the <jats:italic>TP53<\/jats:italic> and <jats:italic>BAX<\/jats:italic> alleles analysed differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere with the development of the disease.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2006.00585.x","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T10:19:24Z","timestamp":1141294764000},"page":"141-144","source":"Crossref","is-referenced-by-count":10,"title":["No evidence for association of the <i>TP53<\/i> 12139 and the <i>BAX<\/i>\u2212248 polymorphisms with endemic pemphigus foliaceus (<i>fogo selvagem<\/i>)"],"prefix":"10.1111","volume":"33","author":[{"given":"K. F.","family":"K\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Petzl\u2010Erler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532296"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050353"},{"key":"e_1_2_6_5_1","first-page":"2392","article-title":"P53 codon 72 polymorphism and rheumatoid arthritis","volume":"28","author":"Lee Y.H.","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456932"},{"key":"e_1_2_6_7_1","unstructured":"Miller M.P.(1997) RxC: a program for the analysis of contingency tables via metropolis algorithm computer.Departament of Biology Sciences Northern Arizona University Flagstaff AZ."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363939"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.08.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1989.tb01684.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(02)00032-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12014.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00049-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00378-6"},{"key":"e_1_2_6_15_1","unstructured":"Schneider R.F. Roessly D.&Excofier L.(2000) ARLEQUIN: a software for population genetic data analysis version 2000.Genetics and Biometry Laboratories Department of Antrophology University of G\u00e8neve G\u00e8neve."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01358.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000018795.05766.1f"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-313X.2006.00585.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-313X.2006.00585.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:49:24Z","timestamp":1696981764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-313X.2006.00585.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1744-313X.2006.00585.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-313x.2006.00585.x","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,2]]}}}