{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:27:33Z","timestamp":1788586053583,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T00:00:00Z","timestamp":1151020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recently, a gain of function variant C1858T of the lymphoid\u2010specific protein tyrosine phosphatase non\u2010receptor (LYP, <jats:italic>PTPN22<\/jats:italic>) gene has been reported to be associated with several autoimmune disorders including Graves\u2019 disease, type 1 diabetes, rheumatoid arthritis and vitiligo. The present study was carried out in 80 patients with sporadic idiopathic hypoparathyroidism (SIH) [43 males and 37 females, mean \u00b1 SD age and duration of symptoms 32.5\u00a0\u00b1\u00a014.1\u00a0years and 6.7\u00a0\u00b1\u00a07.2\u00a0years (range 1\u00a0day to 35\u00a0years), respectively] and 193 healthy controls (male : female ratio 91:102, mean \u00b1 SD age, 43.1\u00a0\u00b1\u00a011.6 years) to assess association of 1858T allele with the disease. Polymerase chain reaction\u2013restriction fragment length polymorphism analysis was performed to genotype C1858T variant. The frequency of occurrence of 1858T allele was 4\/160 (2.5%) in SIH and 5\/386 (1.3%) in the control alleles (odds ratio 1.95, 95% CI 0.51\u20137.37). Thus, the present study reveals that 1858T allele is rare (1.3%) in Asian Indians. The trend of higher prevalence of 1858T allele in patients with SIH needs to be studied further in other population with higher rate of the allele to support the autoimmune basis of the disease.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2006.00604.x","type":"journal-article","created":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T13:46:05Z","timestamp":1151070365000},"page":"237-240","source":"Crossref","is-referenced-by-count":11,"title":["Protein tyrosine phosphatase non\u2010receptor type 22 (<i>PTPN22<\/i>) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian 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