{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T19:54:49Z","timestamp":1720468489570},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,3]],"date-time":"2006-07-03T00:00:00Z","timestamp":1151884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The functional single nucleotide polymorphism rs1801274 in the <jats:italic>FCGR2A<\/jats:italic> gene (His131Arg) influences the efficiency of hIgG2 binding, the main isotype produced in response to encapsulated bacteria like <jats:italic>Streptococcus pneumoniae<\/jats:italic> and <jats:italic>Haemophilus influenzae<\/jats:italic>. In contrast to the receptor with the His131 allele, Fc\u03b3RIIa\u2010Arg131 binds hIgG2 poorly and carriers of this variant have been shown to be much more susceptible to succumb to bacterial pneumonia or meningitis. As bacteraemic pneumonia is one of the leading causes of death in elderly individuals, we hypothesized that the Arg131 variant could be a major mortality factor in the old. We analysed the <jats:italic>FCGR2A<\/jats:italic>\u2010His131Arg polymorphism in a group of 408 German centenarians and two samples of younger Germans aged 60\u201375 and 18\u201349\u00a0years, respectively. No statistically significant differences were observed between the three age groups, neither at the allele nor at the genotype level. Apparently, the ability to reach old age is largely unaffected by the genetically determined efficacy of the <jats:italic>FCGR2A<\/jats:italic>\u2010based immune response. However, the severely reduced ability of <jats:italic>FCGR2A\u2010<\/jats:italic>131Arg carriers to eliminate encapsulated bacteria must apparently be compensated by an alternative mechanism, possibly involving other genetic survival factors.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2006.00613.x","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T21:25:05Z","timestamp":1152134705000},"page":"277-279","source":"Crossref","is-referenced-by-count":3,"title":["The <i>FCGR2A<\/i>\u2014 Arg131 variant is no major mortality factor in the elderly \u2014 evidence from a German centenarian study"],"prefix":"10.1111","volume":"33","author":[{"given":"B. K.","family":"Flesch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nikolaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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