{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:21:59Z","timestamp":1772670119148,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Brucellosis is a worldwide zoonosis. Infection with <jats:italic>Brucella<\/jats:italic> species results in the activation of cell\u2010mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possible association between Th1 cytokines gene polymorphism and brucellosis. Different genotypes of TNF\u2010\u03b1, IFN\u2010\u03b3 and IL\u20102 were determined by polymerase chain reaction\u2013sequence\u2010specific primer in 47 patients with brucellosis and in 166 healthy controls. Allele frequencies of these genotypes were compared using the \u03c7<jats:sup>2<\/jats:sup> test. The results showed a significant difference in the TNF\u2010\u03b1 genotype GG\/GG in patients in comparison with controls (76.7% vs. 21%) (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.001, OR\u00a0=\u00a012.42, 95%CI 5.7\u201327.7). There was no significant difference in the frequency distribution of the IFN\u2010\u03b3 genotypes between two groups. IL\u20102 GG genotype at position \u2212330 was about two times more common in cases than in controls, but the difference was not significant (10.6 vs. 4.6 <jats:italic>P<\/jats:italic> value\u00a0=\u00a00.09).This study shows that genetically low producers of TNF\u2010\u03b1 are possibly susceptible to brucellosis and raise doubt about the role of gene polymorphism of INF\u2010\u03b3 in brucellosis which was demonstrated in previous studies. It seems that patients with brucellosis did not have a defect in producing IL\u20102 with even a trend towards producing higher amounts of this cytokine.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2006.00626.x","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T15:32:20Z","timestamp":1158593540000},"page":"355-359","source":"Crossref","is-referenced-by-count":17,"title":["Th\u20101 cytokines gene polymorphism in human brucellosis"],"prefix":"10.1111","volume":"33","author":[{"given":"S.","family":"Davoudi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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