{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:59:02Z","timestamp":1778662742287,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:00:00Z","timestamp":1170806400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study we aimed to investigate IVS3 +17T\/C single nucleotide polymorphism (SNP) of CD28 gene, +49A\/G and \u2212318C\/T SNPs of CTLA\u20104 gene in patients with Beh\u00e7et's disease (BD) and their potential association to the main clinical features of the disease. These polymorphisms were investigated in a Turkish population of 123 patients with BD and 179 healthy controls, by using PCR\u2010RFLP technique. HLA\u2010B*51 genotype was also studied in both groups by using PCR\u2010SSP. The frequency of IVS3 +17TC genotype of the CD28 gene was significantly increased in BD patients compared to controls (43.6% vs. 31.2%, OR\u00a0=\u00a01.663, 95% CI\u00a0=\u00a01.033\u20132.679, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039). CTLA\u20104 +49GG genotype frequency was found to be significantly lower in patients with BD than those of healthy controls (4% vs. 10.6%, OR\u00a0=\u00a00.357, 95% CI\u00a0=\u00a00.130\u20130.983, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). Genotype and allele frequencies of the CTLA\u20104\u2013318C\/T polymorphism between the BD and healthy control groups were not significantly different (12.2% vs. 10.6%, OR\u00a0=\u00a01.170, 95% CI\u00a0= 0.570\u20132.402, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.713). There were no associations between the studied polymorphisms and the main clinical features of BD. The frequencies of HLA\u2010B*51 were 60.3% and 30.7% in BD and control groups, respectively (OR\u00a0= 3.429, 95% CI\u00a0=\u00a02.115\u20135.559, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). Association between HLA\u2010B*51 and each studied polymorphism did not reach to significant levels (OR\u00a0= 0.479, 95% CI\u00a0= 0.228\u20131.004, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.064 for CD28 IVS3 +17TT genotype; OR\u00a0=\u00a02.180, 95% CI\u00a0=\u00a01.025\u20134.639, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.061 for TC genotype; OR\u00a0=\u00a01.570, 95% CI\u00a0= 0.870\u20132.836, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.146 for C allele). These results may suggest that CD28 IVS3 +17TC genotype may be a risk factor for the development of BD, on the contrary CTLA\u20104 +49GG genotype may be protective in the studied Turkish population.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2007.00655.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T11:01:08Z","timestamp":1170846068000},"page":"45-49","source":"Crossref","is-referenced-by-count":46,"title":["Analysis of CD28 and CTLA\u20104 gene polymorphisms in Turkish patients with Behcet's disease"],"prefix":"10.1111","volume":"34","author":[{"given":"R.","family":"Gunesacar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Erken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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