{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:22:02Z","timestamp":1763684522972},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T00:00:00Z","timestamp":1171843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As matrix metalloproteinases (MMPs) play an important role in rheumatoid arthritis, we investigated whether variation in MMP genes was associated with functional disability in rheumatoid arthritis patients. A cohort of patients with seropositive rheumatoid arthritis were recruited and genotyped for the MMP1\u20101607 1G\u00a0&gt;\u00a02G, MMP3\u20101612 5A\u00a0&gt;\u00a06A, MMP7\u2010153C\u00a0&gt;\u00a0T, MMP7\u2010181G\u00a0&gt;\u00a0A, MMP12\u201082A\u00a0&gt;\u00a0G and MMP13\u201077A\u00a0&gt;\u00a0G polymorphisms. Genotypes were then analysed in relation to functional disability assessed by Steinbrocker index and Health Assessment Questionnaire (HAQ) score. We detected an association between the MMP13\u201077\u00a0A\u00a0&gt; G polymorphism and Steinbrocker index, with patients of the A\/A genotype having higher score than patients of the A\/G or G\/G genotype (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.005), and the association remained significant after adjusting for age, sex, erythrocyte sedimentation rate, presence of erosive disease, Ritchie score, prednisolone therapy and years of diagnosis (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.003). We also observed a relationship of Steinbrocker index with the MMP3\u20101612 5A\u00a0&gt;\u00a06A, MMP7\u2010181\u00a0A\u00a0&gt;\u00a0G and MMP12\u201082A\u00a0&gt;\u00a0G polymorphisms (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.082, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045). No association was detected between the MMP1\u20101607 1G\u00a0&gt;\u00a02G and MMP7\u2010153C\u00a0&gt;\u00a0T polymorphisms and either Steinbrocker index or HAQ score. These results suggest that MMP3, MMP7, MMP12 and MMP13 genotypes may play a role in determining functional status of rheumatoid arthritis.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2007.00664.x","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:27:37Z","timestamp":1171888057000},"page":"81-85","source":"Crossref","is-referenced-by-count":35,"title":["Variation in the matrix metalloproteinase\u20103, \u20107, \u201012 and \u201013 genes is associated with functional status in rheumatoid arthritis"],"prefix":"10.1111","volume":"34","author":[{"given":"S.","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Patodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Walker\u2010Bone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Reading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dennison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200102)45:1<101::AID-ANR90>3.0.CO;2-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00482-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm763"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2741\/1817"},{"key":"e_1_2_6_6_1","first-page":"15","article-title":"Collagenase\u20101 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