{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:54:42Z","timestamp":1775073282918,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Psoriasis vulgaris is a multifactorial disease with an autoimmune component, and T lymphocytes seem to be involved in its aetiology. CTLA\u20104 molecule is an important down\u2010regulator of T\u2010lymphocyte activation, and several polymorphisms of the <jats:italic>CTLA\u20104<\/jats:italic> gene were found to be associated with some autoimmune diseases. We examined whether single nucleotide polymorphisms (SNPs) in the <jats:italic>CTLA\u20104<\/jats:italic> gene, CT60A&gt;G and +49A&gt;G, are associated with psoriasis vulgaris. Alleles of these two SNPs were determined by the polymerase chain reaction\u2013restriction fragment length polymorphism method. Both the CT60G&gt;A and the +49A&gt;G alleles and genotypes were distributed similarly in patients and controls. Although the two SNPs studied here in Poles were in linkage disequilibrium, all four possible two\u2010locus haplotypes were found, one of them rare; of the remaining three, the haplotype +49G, CT60G was significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019, <jats:italic>OR<\/jats:italic>\u00a0=\u00a00.58, 95%CI\u00a0=\u00a00.37\u20130.91) less frequent in the patient group with disease onset between the ages of 21 and 40\u00a0years than in controls and the other patient groups, whereas the frequencies of the other haplotypes were similar in patients and controls. To the authors\u2019 knowledge, this is the first study on <jats:italic>CTLA\u20104<\/jats:italic> CT60 allele frequencies in psoriasis.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2007.00736.x","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T09:03:14Z","timestamp":1285146194000},"page":"51-55","source":"Crossref","is-referenced-by-count":9,"title":["Distribution of the <i>CTLA\u20104<\/i> single nucleotide polymorphisms CT60G&gt;A and +49A&gt;G in psoriasis vulgaris patients and control individuals from a Polish Caucasian 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