{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T08:46:21Z","timestamp":1764492381193},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1624,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1111\/j.1744-313x.2011.01006.x","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T06:57:55Z","timestamp":1300777075000},"page":"295-301","source":"Crossref","is-referenced-by-count":24,"title":["IL-1 cluster gene polymorphisms in Turkish patients with Beh\u00e7et\u2019s disease"],"prefix":"10.1111","volume":"38","author":[{"given":"A. A.","family":"\u00d6z\u00e7imen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dilek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dc.","family":"Bing\u00f6l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sar\u0131cao\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sarand\u00f6l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6.","family":"Ta\u015fkap\u0131l\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yurtkuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Yurtkuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. B.","family":"Oral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,22]]},"reference":[{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1468-3083.2004.00907.x","article-title":"Serum interleukin-6, procalcitonin and c-reactive protein levels in subjects with active Behcet\u2019s disease","volume":"18","author":"Adam","year":"2004","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.47102\/annals-acadmedsg.V33N5p596","article-title":"Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet\u2019s disease","volume":"33","author":"Akdeniz","year":"2004","journal-title":"Annals of the Academy of Medicine, Singapore"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00403-007-0794-1","article-title":"Relationship between periodontal findings and specific polymorphisms of interleukin-1alpha and -1beta in Turkish patients with Behcet\u2019s disease","volume":"300","author":"Akman","year":"2008","journal-title":"Archives of Dermatological Research"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10067-006-0503-z","article-title":"T helper 1 type cytokines polymorphisms: association with susceptibility to Behcet\u2019s disease","volume":"26","author":"Alayli","year":"2007","journal-title":"Clinical Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/art.20334","article-title":"Involvement of chemokines and th1 cytokines in the pathogenesis of mucocutaneous lesions of Behcet\u2019s disease","volume":"50","author":"Ben Ahmed","year":"2004","journal-title":"Arthritis and Rheumatism"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1744-313X.1998.tb01146.x","article-title":"Human cytokine gene nucleotide sequence alignments, 1998","volume":"25","author":"Bidwell","year":"1998","journal-title":"European Journal of Immunogenetics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.gene.6363645","article-title":"Cytokine gene polymorphism in human disease: on-line databases","volume":"1","author":"Bidwell","year":"1999","journal-title":"Genes and Immunity"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.gene.6363733","article-title":"Cytokine gene polymorphism in human disease: on-line databases, supplement 1","volume":"2","author":"Bidwell","year":"2001","journal-title":"Genes and Immunity"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00296-009-1134-x","article-title":"TNF-alpha gene polymorphisms in iranian azeri Turkish patients with Behcet\u2019s disease","volume":"30","author":"Bonyadi","year":"2009","journal-title":"Rheumatology International"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.gene.6364032","article-title":"Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis","volume":"5","author":"Carter","year":"2004","journal-title":"Genes and Immunity"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0888-7543(91)90219-5","article-title":"Chromosomal location of murine and human IL-1 receptor genes","volume":"9","author":"Copeland","year":"1991","journal-title":"Genomics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.0906-6705.2005.00253.x","article-title":"Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet\u2019s disease","volume":"14","author":"Coskun","year":"2005","journal-title":"Experimental Dermatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2249.1995.tb05549.x","article-title":"Cytokine production by normal human monocytes: Inter-subject variation and relationship to an IL-1 receptor antagonist (il-1ra) gene polymorphism","volume":"99","author":"Danis","year":"1995","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB14|cit14","first-page":"S73","article-title":"Cytokine gene polymorphisms in Behcet\u2019s disease and their association with clinical and laboratory findings","volume":"27","author":"Dilek","year":"2009","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0167-5699(91)90142-G","article-title":"Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro","volume":"12","author":"Dinarello","year":"1991","journal-title":"Immunology Today"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1056\/NEJM199301143280207","article-title":"The role of interleukin-1 in disease","volume":"328","author":"Dinarello","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00296-003-0400-6","article-title":"Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behcet\u2019s disease","volume":"25","author":"Duzgun","year":"2005","journal-title":"Rheumatology International"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB19|cit19","first-page":"S37","article-title":"Synovial fluid cytokine levels in Behcet\u2019s disease","volume":"19","author":"Ertenli","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (il-6) gene on il-6 transcription and plasma il-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"Journal of Clinical Investigation"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1093\/nar\/14.8.3167","article-title":"Complete nucleotide sequence of the gene for human interleukin 1 alpha","volume":"14","author":"Furutani","year":"1986","journal-title":"Nucleic Acids Research"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB22|cit22","first-page":"S6","article-title":"Behcet\u2019s disease: an update on the pathogenesis","volume":"19","author":"Gul","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1744-313X.2007.00655.x","article-title":"Analysis of cd28 and ctla-4 gene polymorphisms in Turkish patients with Behcet\u2019s disease","volume":"34","author":"Gunesacar","year":"2007","journal-title":"International Journal of Immunogenetics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/030097402320318387","article-title":"Cytokine profile in Behcet\u2019s disease patients. Relationship with disease activity","volume":"31","author":"Hamzaoui","year":"2002","journal-title":"Scandinavian Journal of Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/01.ATV.0000150039.60906.02","article-title":"Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro","volume":"25","author":"Iacoviello","year":"2005","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB26|cit26","first-page":"1078","article-title":"Criteria for diagnosis of Behcet\u2019s disease","volume":"335","author":"International Study Group for Behcet\u2019s Disease.","year":"1990","journal-title":"Lancet"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/rheumatology\/keg232R","article-title":"Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet\u2019s disease","volume":"42","author":"Karasneh","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/rheumatology\/keh195","article-title":"Increased entry of cd4+ T cells into the th1 cytokine effector pathway during T-cell division following stimulation in Behcet\u2019s disease","volume":"43","author":"Koarada","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB29|cit29","first-page":"S20","article-title":"Cytokines, cytokine antagonists and soluble adhesion molecules in patients with ocular Behcet\u2019s disease treated with human recombinant interferon-alpha2a. Results of an open study and review of the literature","volume":"23","author":"Kotter","year":"2005","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1182\/blood.V73.1.104.104","article-title":"The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13","volume":"73","author":"Lafage","year":"1989","journal-title":"Blood"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/1043-4666(92)90041-O","article-title":"Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene","volume":"4","author":"Lennard","year":"1992","journal-title":"Cytokine"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1136\/bjo.87.10.1264","article-title":"T-bet expression is upregulated in active Behcet\u2019s disease","volume":"87","author":"Li","year":"2003","journal-title":"British Journal of Ophthalmology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin 1B and interleukin 1rn polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/ndt\/16.7.1368","article-title":"Polymorphism of the cytokine genes in hospitalized patients with puumala hantavirus infection","volume":"16","author":"Makela","year":"2001","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB35|cit35","first-page":"541","article-title":"Ethnicity greatly influences the interleukin-1 gene cluster(IL-1B promoter, exon-5 and IL-1Ra) polymorphisms: a pilot study of a north indian population","volume":"6","author":"Manchanda","year":"2005","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0888-7543(88)90019-5","article-title":"Chromosomal localization of the human interleukin 1 alpha (il-1 alpha) gene","volume":"2","author":"Modi","year":"1988","journal-title":"Genomics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s002510050530","article-title":"Il1B gene polymorphisms influence the course and severity of inflammatory bowel disease","volume":"49","author":"Nemetz","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/geno.1993.1025","article-title":"The human interleukin-1 receptor antagonist (il1rn) gene is located in the chromosome 2q14 region","volume":"15","author":"Patterson","year":"1993","journal-title":"Genomics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s00296-005-0040-0","article-title":"Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behcet\u2019s disease. Does interleukin-1beta play a major role in Behcet\u2019s synovitis?","volume":"26","author":"Pay","year":"2006","journal-title":"Rheumatology International"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1399-0039.2004.00280.x","article-title":"Hla class I and class II genotyping in patients with Behcet\u2019s disease: a regional study of eastern part of Turkey","volume":"64","author":"Pirim","year":"2004","journal-title":"Tissue Antigens"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2362.1992.tb01480.x","article-title":"A Taql polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro","volume":"22","author":"Pociot","year":"1992","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2370.1999.00122.x","article-title":"In vitro production of ifn-gamma correlates with ca repeat polymorphism in the human ifn-gamma gene","volume":"26","author":"Pravica","year":"1999","journal-title":"European Journal of Immunogenetics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0198-8859(00)00167-1","article-title":"A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production","volume":"61","author":"Pravica","year":"2000","journal-title":"Human Immunology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB44|cit44","first-page":"321","article-title":"Cytokines in Behcet\u2019s disease","volume":"23","author":"Sayinalp","year":"1996","journal-title":"Journal of Rheumatology"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0888-7543(92)90137-H","article-title":"The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci","volume":"13","author":"Steinkasserer","year":"1992","journal-title":"Genomics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/gut.43.1.33","article-title":"Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease","volume":"43","author":"Stokkers","year":"1998","journal-title":"Gut"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/sj.eye.6701580","article-title":"Evaluation of TNF-alpha and IL-1beta polymorphisms in Taiwan Chinese patients with pterygium","volume":"19","author":"Tsai","year":"2005","journal-title":"Eye"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2370.1997.tb00001.x","article-title":"An investigation of polymorphism in the interleukin-10 gene promoter","volume":"24","author":"Turner","year":"1997","journal-title":"European Journal of Immunogenetics"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/jlts.2002.50014","article-title":"Are cytokine gene polymorphisms related to in vitro cytokine production profiles?","volume":"9","author":"Warle","year":"2003","journal-title":"Liver Transplantation"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB50|cit50","first-page":"77","article-title":"Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2","volume":"5","author":"Webb","year":"1986","journal-title":"Lymphokine Research"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1523-1755.2005.00403.x","article-title":"Interleukin-1 gene cluster polymorphisms predict risk of ESRD","volume":"68","author":"Wetmore","year":"2005","journal-title":"Kidney International"},{"key":"10.1111\/j.1744-313X.2011.01006.x-BIB52|cit52","first-page":"345","article-title":"Elevated serum interleukin 1 receptors and interleukin 1B in patients with Behcet\u2019s disease: correlations with disease activity and severity","volume":"31","author":"Yosipovitch","year":"1995","journal-title":"Israel Journal of Medical Sciences"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-313X.2011.01006.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1744-313X.2011.01006.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T10:17:07Z","timestamp":1712312227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-313X.2011.01006.x"}},"subtitle":["IL-1 cluster gene polymorphisms in BD"],"short-title":[],"issued":{"date-parts":[[2011,3,22]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1744-313x.2011.01006.x","relation":{},"ISSN":["1744-3121"],"issn-type":[{"value":"1744-3121","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3,22]]}}}