{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:37:40Z","timestamp":1775306260111,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T00:00:00Z","timestamp":1319068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>As certain cytokines may play a role in unexplained recurrent spontaneous abortion (RSA) and also some cytokine gene polymorphisms may affect the level of cytokine production, the aim of this study was to investigate the relationship between Chinese RSA and polymorphisms of the genes coding for interleukin (IL)\u20101\u03b2 (\u221231C\/T, \u2212511C\/T, +3954C\/T) and IL\u20106 (\u2212634C\/G). Women (<jats:italic>n<\/jats:italic>\u2003=\u2003162) with at least three consecutive spontaneous abortions and 156 ethnically matched healthy women with at least one successful pregnancy were included. Genotypes were determined using restriction fragment length polymorphism analysis of polymerase chain reaction products. No significant differences were found in the <jats:italic>IL\u20101\u03b2<\/jats:italic>\u221231T, \u2212511T and +3954T distributions between the RSA group and the control group. On the other hand, the frequencies of the <jats:italic>IL\u20106<\/jats:italic>\u2212634GG genotype and \u2212634G allele were significantly decreased in the RSA group versus the control group (genotype: <jats:italic>P<\/jats:italic>\u2003=\u20030.0003; allele: <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.002), suggesting the <jats:italic>IL\u20106<\/jats:italic>\u2212634C\/G polymorphism might be a possible genetic protective factor for RSA.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2011.01049.x","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T09:45:03Z","timestamp":1319103903000},"page":"15-19","source":"Crossref","is-referenced-by-count":20,"title":["Association of <i>IL\u20101\u03b2<\/i> and <i>IL\u20106<\/i> gene polymorphisms with recurrent spontaneous abortion in a Chinese Han 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