{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:36:15Z","timestamp":1784158575500,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The <jats:italic>IFIH1<\/jats:italic> gene is a key factor connecting environmental and genetic factors in the pathogenesis of immune\u2010related diseases. We aimed to investigate whether it has effects on psoriasis, chronic periodontitis and skin test\u2010positive penicillin allergy and to confirm whether these diseases have shared molecular mechanisms originating from shared genetics. Two common variants in <jats:italic>IFIH1<\/jats:italic> were genotyped in 561 patients with psoriasis, 421 patients with chronic periodontitis, 175 patients with skin test\u2010positive penicillin allergy and 1100 shared controls. Then, case\u2013control study was used to analyse the association between <jats:italic>IFIH1<\/jats:italic> and the three diseases. The allele distributions of rs1990760 and rs3747517 in the Chinese population are much different from the European population. The A allele of rs1990760 (OR\u2003=\u20031.30, <jats:italic>P<\/jats:italic>\u2003=\u20035.4\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>) and A\u2010G (rs1990760\/rs3747517) haplotype (OR\u2003=\u20031.31, <jats:italic>P<\/jats:italic>\u2003=\u20033.8\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>) were highly associated with the risk of psoriasis. However, the A allele of rs1990760 (OR\u2003=\u20030.73, <jats:italic>P<\/jats:italic>\u2003=\u20037.8\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>) and A\u2010G haplotype (OR\u2003=\u20030.71, <jats:italic>P<\/jats:italic>\u2003=\u20034.5\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>) were identified as protective factors for chronic periodontitis. <jats:italic>IFIH1<\/jats:italic> affects several immune\u2010related diseases, including psoriasis and chronic periodontitis, and provides a molecular link between genetic susceptibility, viral infections and immune\u2010related diseases. Moreover, we also confirm the hypothesis that shared molecular mechanisms from common genetic variants contribute to a spectrum of immune\u2010related diseases.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2011.01068.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T14:34:06Z","timestamp":1323354846000},"page":"137-143","source":"Crossref","is-referenced-by-count":18,"title":["Genetic variants in <i>IFIH1<\/i> play opposite roles in the pathogenesis of psoriasis and chronic 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