{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:52:42Z","timestamp":1791071562506,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Leprosy is a chronic infectious disease caused by <jats:italic>Mycobacterium leprae<\/jats:italic>, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the <jats:italic>MICA<\/jats:italic> and <jats:italic>HLA\u2010B<\/jats:italic> genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and ethnical background. Of the patients, 153 had multibacillary, 45 paucibacillary and 25 indeterminate leprosy. The aim of this case\u2013control study was to assess whether the <jats:italic>MICA<\/jats:italic> alleles influence susceptibility for leprosy or affect the subtype of the disease in a population of southern Brazil. There were significant differences in frequencies of the <jats:italic>MICA*027<\/jats:italic> allele (4.7% vs 1.8%, <jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.01, OR\u2003=\u20030.37; 95% CI\u2003=\u20030.16\u20130.85) between leprosy patients and controls, and of the <jats:italic>MICA*010<\/jats:italic> (4.5% vs 1.6%, <jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.05, OR\u2003=\u20030.35, 95% CI\u2003=\u20030.13\u20130.97) and <jats:italic>MICA*027<\/jats:italic> alleles (4.7% vs 1.3%, <jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.01; OR\u2003=\u20030.27; 95% CI\u2003=\u20030.09\u20130.79) between multibacillary leprosy patients and the control group. There were no significant differences in the frequency of <jats:italic>MICA<\/jats:italic> alleles between paucibacillary leprosy patients and controls. Thus, the <jats:italic>MICA*027<\/jats:italic> allele is associated with a protective effect for leprosy <jats:italic>per se<\/jats:italic>, while the <jats:italic>MICA*010<\/jats:italic> and <jats:italic>MICA*027<\/jats:italic> alleles are associated with protection against multibacillary leprosy, the most severe clinical subtype.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2011.01074.x","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T07:18:22Z","timestamp":1323847102000},"page":"210-215","source":"Crossref","is-referenced-by-count":14,"title":["Frequencies of <i>MICA<\/i> alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy"],"prefix":"10.1111","volume":"39","author":[{"given":"W.","family":"Sergio do Sacramento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Mazini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A. S.","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. C.","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Sell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. T.","family":"Tsuneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Laguila Visentainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6259"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.727"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300012452"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35059006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb02998.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580612.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03067.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363926"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050536"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01127.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.08.019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822011000500018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5935\/0305-7518.19870042"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.47276\/lr.76.1.5","article-title":"Challenges presented by nerve damage in leprosy","volume":"76","author":"Harboe M.","year":"2005","journal-title":"Leprosy Review"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1395"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4049\/jimmunol.130.4.1784","article-title":"Interleukin 2 mediated immune interferon (IFN\u2010gamma) production by human T cells and T cell subsets","volume":"130","author":"Kasahara T.","year":"1983","journal-title":"The Journal of Immunology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01004.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.2004.00446.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1298"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0126614100"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050655"},{"key":"e_1_2_8_23_1","first-page":"597","article-title":"HLA polymorphism and evaluation of European, African, and Amerindian contribution to the white and mulatto population from Paran\u00e1, Brazil","volume":"72","author":"Probst C.M.","year":"2000","journal-title":"Human Biology"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01142.x"},{"key":"e_1_2_8_25_1","first-page":"255","article-title":"Classification of leprosy according to immunity. A five\u2010group system","volume":"34","author":"Ridley D.S.","year":"1966","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-134"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510100325"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01960-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl229"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364390"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X1997000100008"},{"key":"e_1_2_8_32_1","first-page":"403","article-title":"HLA linked with leprosy in southern China: hLA\u2010linked resistance alleles to leprosy","volume":"67","author":"Wang L.M.","year":"1999","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"key":"e_1_2_8_33_1","first-page":"337","article-title":"Global leprosy situation","volume":"85","author":"World Health Organization","year":"2010","journal-title":"Weekly Epidemiological Record"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.730"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-313X.2011.01074.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-313X.2011.01074.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:10:15Z","timestamp":1698664215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-313X.2011.01074.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1744-313X.2011.01074.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-313x.2011.01074.x","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}